Version 1
: Received: 15 April 2024 / Approved: 15 April 2024 / Online: 16 April 2024 (11:02:57 CEST)
Version 2
: Received: 27 April 2024 / Approved: 28 April 2024 / Online: 29 April 2024 (04:39:44 CEST)
How to cite:
Xiao, D.; Wang, Y.; Gao, C.; Zhang, X.; Feng, W.; Lu, X.; Feng, B. A New Quinazolinone Alkaloid from Rhodiola tibetica Endophytic Fungus Penicillium sp. HJT-A-6. Preprints2024, 2024041012. https://doi.org/10.20944/preprints202404.1012.v1
Xiao, D.; Wang, Y.; Gao, C.; Zhang, X.; Feng, W.; Lu, X.; Feng, B. A New Quinazolinone Alkaloid from Rhodiola tibetica Endophytic Fungus Penicillium sp. HJT-A-6. Preprints 2024, 2024041012. https://doi.org/10.20944/preprints202404.1012.v1
Xiao, D.; Wang, Y.; Gao, C.; Zhang, X.; Feng, W.; Lu, X.; Feng, B. A New Quinazolinone Alkaloid from Rhodiola tibetica Endophytic Fungus Penicillium sp. HJT-A-6. Preprints2024, 2024041012. https://doi.org/10.20944/preprints202404.1012.v1
APA Style
Xiao, D., Wang, Y., Gao, C., Zhang, X., Feng, W., Lu, X., & Feng, B. (2024). A New Quinazolinone Alkaloid from Rhodiola tibetica Endophytic Fungus Penicillium sp. HJT-A-6. Preprints. https://doi.org/10.20944/preprints202404.1012.v1
Chicago/Turabian Style
Xiao, D., Xuan Lu and Baomin Feng. 2024 "A New Quinazolinone Alkaloid from Rhodiola tibetica Endophytic Fungus Penicillium sp. HJT-A-6" Preprints. https://doi.org/10.20944/preprints202404.1012.v1
Abstract
A new quinazolinone alkaloid, named peniquinazolinone A (1), as well as eleven known compounds, 2-(2-hydroxy-3-phenylpropionamido)-N-methylbenzamide (2), viridicatin (3), viridicatol (4), (±)-cyclopeptin (5a/5b), dehydrocyclopeptin (6), cyclopenin (7), cyclopenol (8), methyl-indole-3-carboxylate (9), 2,5-dihydroxyphenyl acetate (10), methyl m-hydroxyphenylacetate (11), conidiogenone B (12), was isolated from the endophytic Penicillium sp. HJT-A-6 derived from the stem of Rhodiola tibetica. The chemical structures of all compounds were elucidated by comprehensive spectroscopic analysis, including 1D, 2D NMR and HRESIMS. The absolute configuration at C-13 of peniquinazolinone A (1) was established by applying the modified Mosher’s method. Compounds 2, 3, and 7 exhibited an optimal promoting effect on the seed germination of Rhodiola tibetica at a concentration of 0.01 mg/mL, while the optimal concentration for compounds 4 and 9 to promote Rhodiola tibetica seed germination is 0.001 mg/mL. Compound 12 showed optimal seed-germination-promoting activity at a concentration of 0.01 mg/mL. Compared with the positive drug 6-benzyladenine (6-BA), compounds 2, 3, 4, 7, 9, and 12 could extend the seed-germination period of Rhodiola tibetica up to the 11th day.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
