Aparicio Acevedo, D.F.; Ortiz Villamizar, M.C.; Kouznetsov, V.V. Three-Step Synthesis of N-(7-chloro-4-morpholinoquinolin-2-yl)benzamide from 4,7-Dichloroquinoline. Molbank2024, 2024, M1796.
Aparicio Acevedo, D.F.; Ortiz Villamizar, M.C.; Kouznetsov, V.V. Three-Step Synthesis of N-(7-chloro-4-morpholinoquinolin-2-yl)benzamide from 4,7-Dichloroquinoline. Molbank 2024, 2024, M1796.
Aparicio Acevedo, D.F.; Ortiz Villamizar, M.C.; Kouznetsov, V.V. Three-Step Synthesis of N-(7-chloro-4-morpholinoquinolin-2-yl)benzamide from 4,7-Dichloroquinoline. Molbank2024, 2024, M1796.
Aparicio Acevedo, D.F.; Ortiz Villamizar, M.C.; Kouznetsov, V.V. Three-Step Synthesis of N-(7-chloro-4-morpholinoquinolin-2-yl)benzamide from 4,7-Dichloroquinoline. Molbank 2024, 2024, M1796.
Abstract
The quinoline derivative, N-(7-chloro-4-morpholinoquinolin-2-yl)benzamide, was synthesized in a conventional three-step procedure from 4,7-dichloroquinoline using N-oxidation reaction/C2-amidation reaction/C4 SNAr reaction sequence. The structure of the compound was fully characterized by FT-IR, 1H‐, 13C-NMR, DEPT-135°, and ESI-MS techniques. Its physicochemical parameters (Lipinski’s descriptors) were also calculated using the online SwissADME database. Such derivatives are relevant therapeutic agents exhibiting potent anticancer, antibacterial, antifungal, and antiparasitic properties.
Chemistry and Materials Science, Organic Chemistry
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