Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

Platelet Biorheology and Mechanobiology in Thrombosis and Hemostasis: Perspectives from Multiscale Computation

Rukiye Tuna
,
Wenjuan Yi
,
Esmeralda Crespo Cruz
,
JP Romero
,
Yi Ren
,
Jingjiao Guan
,
Yan Li
ORCID logo ,
Yuefan Deng
ORCID logo ,
Danny Bluestein
ORCID logo ,
Z. Leonardo Liu
,
Jawaad Sheriff
* ORCID logo
Version 1 : Received: 13 February 2024 / Approved: 14 February 2024 / Online: 14 February 2024 (12:07:28 CET)
Version 2 : Received: 19 April 2024 / Approved: 22 April 2024 / Online: 23 April 2024 (17:50:04 CEST)

A peer-reviewed article of this Preprint also exists.

Tuna, R.; Yi, W.; Crespo Cruz, E.; Romero, J.; Ren, Y.; Guan, J.; Li, Y.; Deng, Y.; Bluestein, D.; Liu, Z.L.; Sheriff, J. Platelet Biorheology and Mechanobiology in Thrombosis and Hemostasis: Perspectives from Multiscale Computation. Int. J. Mol. Sci. 2024, 25, 4800. Tuna, R.; Yi, W.; Crespo Cruz, E.; Romero, J.; Ren, Y.; Guan, J.; Li, Y.; Deng, Y.; Bluestein, D.; Liu, Z.L.; Sheriff, J. Platelet Biorheology and Mechanobiology in Thrombosis and Hemostasis: Perspectives from Multiscale Computation. Int. J. Mol. Sci. 2024, 25, 4800.

Abstract

Thrombosis is the pathological clot formation under abnormal hemodynamic conditions, which can result in vascular obstruction, causing ischemic strokes and myocardial infarction. Thrombus growth under moderate to low shear (<1000 s-1) relies on platelet activation and coagulation. Thrombosis at elevated high shear rates (>10,000 s-1) is predominantly driven by unactivated platelet binding and aggregating mediated by von Willebrand factor (VWF), while platelet activation and coagulation are secondary in supporting and reinforcing the thrombus. Given the molecular and cellular level information it can access, multiscale computational modelling informed by biology can provide new pathphysiological mechanisms that are otherwise not accessible experimentally, holding promise for novel first-principle-based therapeutics. In this review, we summarize the key aspects of platelet biorheology and mechanobiology, focusing on the molecular and cellular scale events and how they build up to thrombosis through platelet adhesion and aggregation in the presence or absence of platelet activation. In particular, we highlight recent advancements in multiscale modeling of platelet biorheology and mechanobiology and how they can lead to better prediction and quantification of thrombus formation, exemplifying the exciting paradigm of digital medicine.

Keywords

von Willebrand factor; platelet margination; platelet adhesion; shear-induced platelet aggregation; platelet mechanobiology; biorheology; platelet activation; thrombosis

Subject

Engineering, Bioengineering

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.