Version 1
: Received: 30 January 2024 / Approved: 30 January 2024 / Online: 30 January 2024 (10:24:25 CET)
How to cite:
Liu, M.; Zhang, X.; Chen, T. Crimped PLA Fibers with Three Levels of Pore Structure Promote Rapid Endothelialization of Blood Vessels. Preprints2024, 2024012102. https://doi.org/10.20944/preprints202401.2102.v1
Liu, M.; Zhang, X.; Chen, T. Crimped PLA Fibers with Three Levels of Pore Structure Promote Rapid Endothelialization of Blood Vessels. Preprints 2024, 2024012102. https://doi.org/10.20944/preprints202401.2102.v1
Liu, M.; Zhang, X.; Chen, T. Crimped PLA Fibers with Three Levels of Pore Structure Promote Rapid Endothelialization of Blood Vessels. Preprints2024, 2024012102. https://doi.org/10.20944/preprints202401.2102.v1
APA Style
Liu, M., Zhang, X., & Chen, T. (2024). Crimped PLA Fibers with Three Levels of Pore Structure Promote Rapid Endothelialization of Blood Vessels. Preprints. https://doi.org/10.20944/preprints202401.2102.v1
Chicago/Turabian Style
Liu, M., Xiaojing Zhang and Tao Chen. 2024 "Crimped PLA Fibers with Three Levels of Pore Structure Promote Rapid Endothelialization of Blood Vessels" Preprints. https://doi.org/10.20944/preprints202401.2102.v1
Abstract
Electrospun fiber scaffolds are widely used in small diameter vascular tissue engineering because they mimick organizational structure and biological function of natural extracellular matrix. However, there is still one problem of low patency rate in the long term. The main reasons are the mismatch of compliance and the easy formation of thrombus. Therefore, it is very important to promote the rapid endothelialization of small diameter tissue engineering blood vessels by regulating the topological structure and biological properties of electrospun fiber scaffolds. Firstly, crimped polylactic acid (PLA) fibers were prepared by heat treatment to mimick the crimped structure and nonlinear mechanical properties of the elastic membrane of blood vessel wall. It improved effectively the aspect ratio of human umbilical vein endothelial cells (HUVECs) and promoted lateral alignment and growth. Then, crimped PLA fibers with three levels of pore structure were prepared by thermal induced phase separation, vapor induced phase separation and laser ablation to enhance the degree of HUVECs infiltrarion and realize patterned cell growth. Crimped PLA fibers with three levels of pore structure promote rapid endothelialization of blood vessels, which is of great significance to achieve long term patency rate of small diameter tissue engineering blood vessels.
Keywords
Small diameter vascular tissue engineering; Electrospinning; Nonlinear mechanical properties; Topological structure; Rapid endothelialization of blood vessels
Subject
Chemistry and Materials Science, Biomaterials
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
