Chatgilialoglu, C.; Barata-Vallejo, S.; Gimisis, T. Radical Reactions in Organic Synthesis: Exploring In-, on-, and with-Water Methods. Molecules2024, 29, 569.
Chatgilialoglu, C.; Barata-Vallejo, S.; Gimisis, T. Radical Reactions in Organic Synthesis: Exploring In-, on-, and with-Water Methods. Molecules 2024, 29, 569.
Chatgilialoglu, C.; Barata-Vallejo, S.; Gimisis, T. Radical Reactions in Organic Synthesis: Exploring In-, on-, and with-Water Methods. Molecules2024, 29, 569.
Chatgilialoglu, C.; Barata-Vallejo, S.; Gimisis, T. Radical Reactions in Organic Synthesis: Exploring In-, on-, and with-Water Methods. Molecules 2024, 29, 569.
Abstract
Radical reactions in water or aqueous media are important for organic synthesis, realizing high yielding processes under non-toxic and environmentally friendly conditions. This overview includes (i) a general introduction to organic chemistry in water and aqueous media, (ii) synthetic approaches in-, on- and with-water as well as in heterogeneous phase, (iii) reaction of carbon-centered radicals with water (or deuterium oxide) activated through coordination with various Lewis acids, (iv) photocatalysis in water and aqueous media, and (v) synthetic applications bioinspired from naturally occurring processes. A wide range of chemical processes and synthetic strategies under different experimental conditions have been reviewed that lead to important functional group translocation and transformation reactions, leading to the preparation of complex molecules. These results reveal how water as a solvent/medium/reagent in radical chemistry has matured over the last two decades and how further discoveries are foreseen to come in the near future.
Keywords
organic synthesis; radical reactions; water and aqueous media; on water reactions; water coordination with Lewis acids; photocatalysis; bioinspired reactions
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
