Version 1
: Received: 9 October 2023 / Approved: 12 October 2023 / Online: 12 October 2023 (16:24:30 CEST)
How to cite:
Sathish, T.; Sasikumar, M.; Demissie, G.D.; ParmodKumar, T.A.; Oldenburg, B.; Oommen, A.M. Recalibration of Framingham Risk Score for Predicting 10-Year Cardiovascular Disease Risk in a South Indian Population. Preprints2023, 2023100816. https://doi.org/10.20944/preprints202310.0816.v1
Sathish, T.; Sasikumar, M.; Demissie, G.D.; ParmodKumar, T.A.; Oldenburg, B.; Oommen, A.M. Recalibration of Framingham Risk Score for Predicting 10-Year Cardiovascular Disease Risk in a South Indian Population. Preprints 2023, 2023100816. https://doi.org/10.20944/preprints202310.0816.v1
Sathish, T.; Sasikumar, M.; Demissie, G.D.; ParmodKumar, T.A.; Oldenburg, B.; Oommen, A.M. Recalibration of Framingham Risk Score for Predicting 10-Year Cardiovascular Disease Risk in a South Indian Population. Preprints2023, 2023100816. https://doi.org/10.20944/preprints202310.0816.v1
APA Style
Sathish, T., Sasikumar, M., Demissie, G.D., ParmodKumar, T.A., Oldenburg, B., & Oommen, A.M. (2023). Recalibration of Framingham Risk Score for Predicting 10-Year Cardiovascular Disease Risk in a South Indian Population. Preprints. https://doi.org/10.20944/preprints202310.0816.v1
Chicago/Turabian Style
Sathish, T., Brian Oldenburg and Anu Mary Oommen. 2023 "Recalibration of Framingham Risk Score for Predicting 10-Year Cardiovascular Disease Risk in a South Indian Population" Preprints. https://doi.org/10.20944/preprints202310.0816.v1
Abstract
1. Background: Cardiovascular diseases (CVDs) are India’s leading cause of mortality. This study aimed to recalibrate the original Framingham Risk Score (FRS) equations among adults in Kerala state. 2. Methods: Baseline survey data from the Kerala Diabetes Prevention Program were analyzed: 921 males and 567 females for lipid-based FRS scores and 1042 males and 646 females for BMI-based FRS scores. Recalibration of the original FRS scores was performed using local data on CVD risk factors and CVD mortality. 3. Results: Among males, the median 10-year CVD risk with the recalibrated lipid-based FRS score was 7.34 (IQR 4.33-12.42), compared with the original score of 8.88 (5.23-14.87) (p<0.001). For BMI-based FRS scores, the median 10-year CVD risk was 7.40 (4.27-11.83) with the recalibrated score, compared to 9.32 (5.40-14.80) for the original score (p<0.001). In females, the median 10-year CVD risk was 4.83 (2.90-8.36) with the recalibrated score, compared to 2.85 (IQR 1.71-4.98) with the original score (p<0.001). Similarly, the median 10-year CVD risk was 4.66 (2.74-8.81) with the recalibrated BMI-based FRS score, compared to 2.95 (1.72-5.61) with the original score (p<0.001). 4. Conclusions: Recalibrated FRS scores estimated a significantly lower 10-year CVD risk in males and a higher risk in females than the original FRS scores.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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