Version 1
: Received: 23 August 2023 / Approved: 23 August 2023 / Online: 24 August 2023 (02:20:25 CEST)
How to cite:
Park, S. S.; Ha, C.-S. Alkylammonium-Functionalized Hollow Mesoporous Silica Nanocarrier for Cancer Therapy. Preprints2023, 2023081656. https://doi.org/10.20944/preprints202308.1656.v1
Park, S. S.; Ha, C.-S. Alkylammonium-Functionalized Hollow Mesoporous Silica Nanocarrier for Cancer Therapy. Preprints 2023, 2023081656. https://doi.org/10.20944/preprints202308.1656.v1
Park, S. S.; Ha, C.-S. Alkylammonium-Functionalized Hollow Mesoporous Silica Nanocarrier for Cancer Therapy. Preprints2023, 2023081656. https://doi.org/10.20944/preprints202308.1656.v1
APA Style
Park, S. S., & Ha, C. S. (2023). Alkylammonium-Functionalized Hollow Mesoporous Silica Nanocarrier for Cancer Therapy. Preprints. https://doi.org/10.20944/preprints202308.1656.v1
Chicago/Turabian Style
Park, S. S. and Chang-Sik Ha. 2023 "Alkylammonium-Functionalized Hollow Mesoporous Silica Nanocarrier for Cancer Therapy" Preprints. https://doi.org/10.20944/preprints202308.1656.v1
Abstract
In this work, alkylammonium-functionalized hollow mesoporous silica as nonocarrier of drugs was synthesized to realize enhanced cancer therapy by pH stimuli for sustained drug release. First, functionalized hollow mesoporous silica nanoparticles (Hollow MSNs) were synthesized using dodecyl dimethyl(3-sulfopropyl)ammonium hydroxide (DDAPS), sodium dodecyl sulfate (SDS), and triethanolamine as structure-directing agents, and tetraethyl orthosilicate (TEOS) and N-trimethoxysilypropyl-N,N,N-trimethylammonium chloride (TMAPS) as silica sources under basic condition via the sol-gel process. The structure and morphology of the alkylammonium-functionalized hollow mesoporous silica nanoparticles (Hollow MSN-N+CH3) were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), N2 adsorption-desorption analysis, and Fourier-transform infrared (FT-IR) spectroscopy. The functionalized hollow MSNs had a particle size of about 450 nm and a shell thickness of about 60 nm with uniform size. The nanoparticle had a surface area of 408 m2g-1, pore volume of 0.8 cm3g-1 and a uniform pore diameter of 45.9 Å. In the cancer cell viability test with MCF-7 cell, fludarabine-incorporated and alkylammonium-functionalized hollow mesoporous silica nanoparticles (Flu/Hollow MSN-N+CH3) showed excellent cancer cell death comparable with pure fludarabine drug with the controlled drug release by pH stimuli. It is considered that our current materials have the potential applicability as pH-responsive nanocarriers in the field of cancer therapy.
Keywords
Hollow mesoporous silica; Alkylammonium; Fludarabine; Drug delivery; Cancer therapy
Subject
Chemistry and Materials Science, Materials Science and Technology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
