Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Heavy Metal-Based Nanoparticles as High-Performance X-Ray Computed Tomography Contrast Agents

Mohammad Yaseen Ahmad
ORCID logo ,
Shuwen Liu
,
Tirusew Tegafaw
,
Abdullah Khamis Ali Al Saidi
ORCID logo ,
Dejun Zhao
ORCID logo ,
Ying Liu
,
Sung-Wook Nam
ORCID logo ,
Yongmin Chang
* ,
Gang Ho Lee
* ORCID logo
Version 1 : Received: 22 August 2023 / Approved: 22 August 2023 / Online: 23 August 2023 (07:54:09 CEST)

A peer-reviewed article of this Preprint also exists.

Ahmad, M.Y.; Liu, S.; Tegafaw, T.; Saidi, A.K.A.A.; Zhao, D.; Liu, Y.; Nam, S.-W.; Chang, Y.; Lee, G.H. Heavy Metal-Based Nanoparticles as High-Performance X-ray Computed Tomography Contrast Agents. Pharmaceuticals 2023, 16, 1463. Ahmad, M.Y.; Liu, S.; Tegafaw, T.; Saidi, A.K.A.A.; Zhao, D.; Liu, Y.; Nam, S.-W.; Chang, Y.; Lee, G.H. Heavy Metal-Based Nanoparticles as High-Performance X-ray Computed Tomography Contrast Agents. Pharmaceuticals 2023, 16, 1463.

Abstract

Contrast agents developed for X-ray computed tomography (CT) offer extremely valuable tools and techniques in diagnostics via contrast enhancements. Heavy metal-based nanoparticles (NPs) can provide high contrast in CT images. These result from a high density of heavy metal atoms with high X-ray attenuation coefficients that exceed that of iodine (I), which is currently used in hydrophilic organic CT contrast agents. Nontoxicity and colloidal stability are vital characteristics in designing heavy metal-based NPs as CT contrast agents. In addition, the particle size must be small for in vivo renal excretion. In vitro phantom imaging studies can provide X-ray attenuation efficiency, which is a critical parameter for CT contrast agents, and the imaging performance of CT contrast agents can be demonstrated via in vivo experiments. This review focuses on in vitro and in vivo studies of various heavy metal-based NPs (metal: Au, Pt, Pd, Ag, Ce, Gd, Dy, Ho, Yb, Ta, W, and Bi) and provides an outlook on their use as high-performance CT contrast agents.

Keywords

heavy metal-based nanoparticles; X-ray attenuation; contrast agents; in vitro phantom imaging; in vivo imaging

Subject

Chemistry and Materials Science, Medicinal Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.