Review
Version 1
Preserved in Portico This version is not peer-reviewed
Lipid Peroxidation and Antioxidant Protection
Version 1
: Received: 14 July 2023 / Approved: 17 July 2023 / Online: 18 July 2023 (08:57:23 CEST)
Version 2 : Received: 17 August 2023 / Approved: 18 August 2023 / Online: 18 August 2023 (10:02:12 CEST)
Version 2 : Received: 17 August 2023 / Approved: 18 August 2023 / Online: 18 August 2023 (10:02:12 CEST)
A peer-reviewed article of this Preprint also exists.
Valgimigli, L. Lipid Peroxidation and Antioxidant Protection. Biomolecules 2023, 13, 1291. Valgimigli, L. Lipid Peroxidation and Antioxidant Protection. Biomolecules 2023, 13, 1291.
Abstract
Lipid peroxidation (LP) is the most important type of oxidative-radical damage in biological systems, owing to its interplay with ferroptosis and to its role in secondary damage to other biomolecules, such as proteins. The chemistry of LP and its biological consequences are reviewed with focus on the kinetics of the various processes, which helps understand the mechanisms and efficacy of antioxidant strategies. The main types of antioxidants are discussed in terms of structure-activity rationalization, with focus on mechanism and kinetics, as well as on their potential role in modulating ferroptosis. Phenols, pyri(mi)dinols, antioxidants based on heavy chalcogens (Se and Te), diarylamines, ascorbate and others are addressed, along with the latest unconventional antioxidant strategies based on the double-sided role of the superoxide/hydroperoxyl radical system.
Keywords
autoxidation; peroxyl radicals; hydroperoxyl radicals; kinetics, antioxidants; phenols; catechols; nitroxides; thiols; pyridinols
Subject
Chemistry and Materials Science, Medicinal Chemistry
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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