Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Self-Assembled CNF/rGO/Tannin Composite: Study of the Physicochemical and Wound Healing Properties

Katherina Fernández
* ORCID logo ,
Ayleen Llanquileo
,
Monserrat Bustos
,
Valentina Aedo
,
Isleidy Ruiz
,
Sebastián Carrasco
,
Mauricio Tapia
,
Miguel Pereira
ORCID logo ,
Manuel Francisco Melendrez
ORCID logo ,
Claudio Aguayo
ORCID logo ,
Leonard I. Atanase
* ORCID logo
Version 1 : Received: 12 April 2023 / Approved: 13 April 2023 / Online: 13 April 2023 (03:21:21 CEST)

A peer-reviewed article of this Preprint also exists.

Fernández, K.; Llanquileo, A.; Bustos, M.; Aedo, V.; Ruiz, I.; Carrasco, S.; Tapia, M.; Pereira, M.; Meléndrez, M.F.; Aguayo, C.; Atanase, L.I. Self-Assembled CNF/rGO/Tannin Composite: Study of the Physicochemical and Wound Healing Properties. Polymers 2023, 15, 2752. Fernández, K.; Llanquileo, A.; Bustos, M.; Aedo, V.; Ruiz, I.; Carrasco, S.; Tapia, M.; Pereira, M.; Meléndrez, M.F.; Aguayo, C.; Atanase, L.I. Self-Assembled CNF/rGO/Tannin Composite: Study of the Physicochemical and Wound Healing Properties. Polymers 2023, 15, 2752.

Abstract

Plant extracts have been evaluated to determine their bioactivities and their potential use in wound healing. In this study, a conductive composite material, based on graphene oxide (GO), nanocellulose (CNF) and tannins (TA) from pine bark, reduced using polydopamine (PDA), was developed for wound dressing. The amount of CNF and TA was varied in the composite material and a complete characterization including SEM, FTIR, XRD, XPS, TGA was performed. Also, the conductivity, mechanical properties, cytotoxicity, and in vitro wound healing of the materials were evaluated. The results showed a successful physical interaction between CNF, TA and GO. In-creasing the CNF amount in the composite reduced the thermal properties, surface charge and conductivity of the material, but its strength, cytotoxicity and wound healing performance were improved. The TA incorporation slightly reduced the cell viability and migration, which may be associated with the doses used and the chemical composition of the extracts. However, the in vitro obtained results demonstrated that these composite materials can be suitable for wound healing.

Keywords

graphene oxide; nanocellulose; reduced graphene oxide; polydopamine; wound healing

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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