Brief Report
Version 1
Preserved in Portico This version is not peer-reviewed
The Structure of the Membrane Protein of SARS-CoV-2 Resembles the Sugar Transporter semiSWEET
Version 1
: Received: 28 April 2020 / Approved: 29 April 2020 / Online: 29 April 2020 (14:06:19 CEST)
Version 2 : Received: 3 May 2020 / Approved: 4 May 2020 / Online: 4 May 2020 (18:14:23 CEST)
Version 3 : Received: 19 May 2020 / Approved: 20 May 2020 / Online: 20 May 2020 (04:43:42 CEST)
Version 4 : Received: 18 July 2020 / Approved: 19 July 2020 / Online: 19 July 2020 (15:06:53 CEST)
Version 5 : Received: 19 August 2020 / Approved: 20 August 2020 / Online: 20 August 2020 (13:47:23 CEST)
Version 6 : Received: 17 October 2020 / Approved: 19 October 2020 / Online: 19 October 2020 (10:48:05 CEST)
Version 2 : Received: 3 May 2020 / Approved: 4 May 2020 / Online: 4 May 2020 (18:14:23 CEST)
Version 3 : Received: 19 May 2020 / Approved: 20 May 2020 / Online: 20 May 2020 (04:43:42 CEST)
Version 4 : Received: 18 July 2020 / Approved: 19 July 2020 / Online: 19 July 2020 (15:06:53 CEST)
Version 5 : Received: 19 August 2020 / Approved: 20 August 2020 / Online: 20 August 2020 (13:47:23 CEST)
Version 6 : Received: 17 October 2020 / Approved: 19 October 2020 / Online: 19 October 2020 (10:48:05 CEST)
A peer-reviewed article of this Preprint also exists.
Thomas, S. The Structure of the Membrane Protein of SARS-CoV-2 Resembles the Sugar Transporter SemiSWEET. Pathogens and Immunity. 2020;5(1):342-363. Thomas, S. The Structure of the Membrane Protein of SARS-CoV-2 Resembles the Sugar Transporter SemiSWEET. Pathogens and Immunity. 2020;5(1):342-363.
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the disease COVID-19 that has decimated the health and economy of our planet. The virus causes the disease not only in people but also in companion and wild animals. People with diabetes are at risk of the disease. As yet we do not know why the virus is highly successful in causing the pandemic within 3 months of its first report. The structural proteins of SARS include, membrane glycoprotein (M), envelope protein (E), nucleocapsid protein (N) and the spike protein (S). The structure and function of the most abundant structural protein of SARS-CoV-2, the membrane (M) glycoprotein is not fully understood. Using in silico analyses we determined the structure and potential function of the M protein. In silico analyses showed that the M protein of SARS-CoV-2 has a triple helix bundle, form a single 3-transmembrane domain (TM), and are homologous to the prokaryotic sugar transport protein semiSWEET. The advantage and role of sugar transporter like structures in viruses are unknown. If they are involved in energy metabolism, they may aid in the rapid proliferation and replication of the virus. Biological experiments should be performed to validate the presence and function of the semiSWEET sugar transporter.
Keywords
SARS-CoV-2; COVID-19; virus; sugar transporter; SemiSWEET; membrane glycoprotein
Subject
Medicine and Pharmacology, Pulmonary and Respiratory Medicine
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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