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Edge AI Phenomics Tracking Motor Proficiency and Psychosocial Benefits in Sensory- Impaired Children’s Recreational Programs
A. Manoj Prabaharan
Posted: 02 April 2026
In Vitro Inhibition of Pathogens by Polyols: Optical Density-Based Screening and Implications for the Oral-Systemic Axis
Mark Cannon
,Bradley S. Stevenson
Polyols are widely used as non-cariogenic sweeteners in foods and oral care products, yet their comparative activity against diverse oral microbes and their potential relevance to the oral–systemic axis remain incompletely defined. Here, we performed an in vitro, optical-density (OD)-based screening of four polyols—allulose, D-mannose, erythritol, and xylitol—against Streptococcus mutans, Streptococcus anginosus, Candida albicans, and Fusobacterium nucleatum. Cultures were grown with polyols at 1–20% (w/v), and OD600 was recorded at organism-specific endpoints (~24 h). Allulose, erythritol, and xylitol produced strong, concentration-dependent suppression of streptococcal growth at ≥5–10%, whereas C. albicans showed minimal changes across the tested range. F. nucleatum was highly sensitive to allulose, D-mannose, and xylitol at ≥5% (reducing OD to ≤13% of untreated control), while low concentrations of D-mannose and erythritol increased OD above control, suggesting species-specific utilization or stress responses. One-way ANOVA with Tukey’s HSD post hoc testing supported significant between-polyol differences for most concentrations in Streptococcus spp. and F. nucleatum. Collectively, these results identify polyol- and taxon-specific growth phenotypes that can inform the formulation of swallow-safe oral hygiene products and motivate follow-up work in polymicrobial biofilm models and clinical studies targeting oral inflammation and downstream systemic risk.
Polyols are widely used as non-cariogenic sweeteners in foods and oral care products, yet their comparative activity against diverse oral microbes and their potential relevance to the oral–systemic axis remain incompletely defined. Here, we performed an in vitro, optical-density (OD)-based screening of four polyols—allulose, D-mannose, erythritol, and xylitol—against Streptococcus mutans, Streptococcus anginosus, Candida albicans, and Fusobacterium nucleatum. Cultures were grown with polyols at 1–20% (w/v), and OD600 was recorded at organism-specific endpoints (~24 h). Allulose, erythritol, and xylitol produced strong, concentration-dependent suppression of streptococcal growth at ≥5–10%, whereas C. albicans showed minimal changes across the tested range. F. nucleatum was highly sensitive to allulose, D-mannose, and xylitol at ≥5% (reducing OD to ≤13% of untreated control), while low concentrations of D-mannose and erythritol increased OD above control, suggesting species-specific utilization or stress responses. One-way ANOVA with Tukey’s HSD post hoc testing supported significant between-polyol differences for most concentrations in Streptococcus spp. and F. nucleatum. Collectively, these results identify polyol- and taxon-specific growth phenotypes that can inform the formulation of swallow-safe oral hygiene products and motivate follow-up work in polymicrobial biofilm models and clinical studies targeting oral inflammation and downstream systemic risk.
Posted: 02 April 2026
Active Vision for Social Navigation
Jack Vice
,Gita Sukthankar
Posted: 02 April 2026
Impact of a Single Hemodialysis Session on Oxidative Stress-Inducing and Oxidative Damage Biomarkers in End-Stage Kidney Disease Patients
Athina Varemmenou
,Effimia Michail
,Electra Kalaitzopoulou
,Polyxeni Papadea
,Marianna Skipitari
,Marios Papasotiriou
,Evangelos Papachristou
,Dimitrios Goumenos
,Christos D. Georgiou
Posted: 02 April 2026
Hormonal and Emerging Therapeutic Strategies in Endometriosis: Translating Pathophysiology into Targeted Treatment
Sara Perelmuter
Posted: 02 April 2026
Alzheimer’s Disease, Piezo2 Channelopathy, Piezo1 Channelopathy and the Body-Wide Piezo2 System
Balazs Sonkodi
Posted: 02 April 2026
Beyond Random Splits: A Critical Evaluation of Graph Learning Models in Predicting Mutation-Induced Drug Resistance
Zongrui Cheng
,Haoxin Wu
,Dengming Ming
Posted: 02 April 2026
Lipid Nanoparticle-Encapsulated PolyI:C as an Adjuvant Enhances Both Humoral and Cellular Immune Responses to the Hepatitis B Vaccine
Zhixian Zhao
,Bin Wang
,Hao Wang
,Qiang Zhang
,Yunfei Liang
,Yuan Liu
Posted: 02 April 2026
Optimizing Multi-Scalar Multiplication Over Fixed Bases
Saulius Grigaitis
Posted: 02 April 2026
Helium Free MRI System—What Does That Mean for a Decision Maker?
Michael Friebe
Posted: 02 April 2026
Influence of Both La Nina and Island Isolation During COVID-19 on the Epidemiology of Infectious Diseases in New-Caledonia
Pierre-Henri Moury
,Ann-Claire Gourinat
,Maria Suveges
,Méryl Delrieu
,Myrielle Dupont-Rouzeyrol
,Christophe Menkes
,Nathanaëlle Soler
,Cécile Cazorla
,Antoine Biron
,Antoine Flahault
+2 authors
Posted: 02 April 2026
The Effect of Caffeine on Various Forms of Synaptic Plasticity in the CA1 Region of Mouse Hippocampal Slices
Margarita A. Novikova
,Irina A. Korneeva
,Rodion V. Kondratenko
,Georgii M. Nikolaev
,Olga A. Averina
,Irina N. Sharonova
,Alexander V. Latanov
Posted: 02 April 2026
Neuronal Ceroid Lipofuscinosis-Like Disorder in a Dachshund with Sequence Variants in Lysosome-Related Genes
Joan R. Coates
,Kristen Keyes
,Rebecca E.H. Whiting
,Juri Kuroki
,Brandie Morgan-Jack
,Tendai Mhlanga-Mutangadura
,Keiichi Kuroki
,Martin L. Katz
Posted: 02 April 2026
Functional Integration of a Portable Non-Enzymatic Electrochemical Glucose Sensor in Simulation-Based Medical Education Through a Teleconsultation Workflow
Leonel Vasquez-Cevallos
,Darwin Castillo
,Pedro A. Salazar-Carballo
,Paul E.D. Soto-Rodriguez
,Franklin Parrales-Bravo
,Roberto Tolozano-Benites
Posted: 02 April 2026
A Grammar-Based Criterion for Learning Sufficiency in Motion Modeling
Herlindo Hernandez-Ramirez
,Jorge Luis Perez-Ramos
,Daniel Canton-Enriquez
,Ana Marcela Herrera-Navarro
,Hugo Jimenez-Hernandez
Posted: 02 April 2026
The Theory of Plafales: P vs NP Problem Solution
Dmytro Topchyi
Posted: 02 April 2026
Broadband Circularly Polarized Antenna Array with Sequential Rotation Feeding and a Windmill-Shaped Defected Ground Structure
Shiquan Zhang
,Shuaijie Wu
,Xianqiong Wen
,Hongxing Zheng
Posted: 02 April 2026
Fuzzy Nilpotent Lie Algebras: Bases, Isomorphisms, and a Measure of Nilpotency
Giuseppe Filippone
,Mario Galici
,Gianmarco La Rosa
,Federica Piazza
,Marco Elio Tabacchi
Posted: 02 April 2026
From Empirical Microbial Products to Bioinputs 2.0: A Functional and Genomics-Driven Framework in Agricultural Microbiology
Diego Sauka
,Carlos Piccinetti
,Leopoldo Palma
Posted: 01 April 2026
Association Between Thoracic Inlet Size and Cervical Anastomosis Outcomes in Oesophageal Cancer Surgery
Iskan Calli
,Ibrahim Dogan
,Halil Alper Bozkurt
,Mehmet Kadir Bartin
,Ezgi Sonmez
,Sebahattin Celik
Posted: 01 April 2026
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