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Preprint ESSAY | doi:10.20944/preprints201608.0158.v1

A Local Mechanism by which Alcohol Consumption Causes Cancer

Miguel López-Lázaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: alcohol; cancer; ethanol; tobacco; carcinogenesis; oral cavity; pharynx; esophagus; stem cells; stem cell division theory of cancer

Online: 16 August 2016 (09:45:33 CEST)

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Epidemiological data indicate that 5.8% of cancer deaths world-wide are attributable to alcohol consumption. The risk of cancer is higher in tissues in closest contact on ingestion of alcohol, such as the oral cavity, pharynx and esophagus. The risk of these cancers is increased even in people who have only one alcoholic drink per day. However, since ethanol is not mutagenic and the carcinogenic metabolite of ethanol (acetaldehyde) is mostly produced in the liver, it is not clear why alcohol use preferentially exerts a local carcinogenic effect. It is well known that ethanol causes cell death at the concentrations present in alcoholic beverages; however, this effect has been overlooked probably because dead cells cannot give rise to cancer. Here I discuss that the cytotoxic effect of ethanol on the cells lining the oral cavity, pharynx and esophagus activates the division of the stem cells located in deeper layers of the mucosa to replace the dead cells. Every time stem cells divide, they become exposed to unavoidable errors associated with cell division (e.g., mutations arising during DNA replication and chromosomal alterations occurring during mitosis) and also become highly vulnerable to the genotoxic activity of endogenous and exogenous DNA-damaging agents (e.g., reactive oxygen species, acetaldehyde and tobacco carcinogens). Alcohol consumption probably increases the risk of developing cancer of the oral cavity, pharynx and esophagus by promoting the accumulation of cell divisions in the stem cells that maintain these tissues in homeostasis. Because the cytotoxic activity of ethanol is concentration-dependent, the risk of these cancers will not only increase with increasing amounts of ethanol, but also with increasing concentrations; an ounce of whisky is probably more carcinogenic when taken undiluted than when taken mixed with non-alcoholic beverages. The local cytotoxic effect of ethanol can also explain the known synergistic effect of alcohol and tobacco use on the risk of these cancers. Understanding the mechanisms of carcinogenicity of alcohol is important to reinforce the epidemiological evidence and to raise public awareness of the strong link between alcohol consumption and cancer.

Preprint ARTICLE | doi:10.20944/preprints201703.0030.v1

Differences in the Bacteriome of Smokeless Tobacco Products with Different Oral Carcinogenicity: Compositional and Predicted Functional Analysis

Nezar Noor Al-hebshi, Fahd Ali Alharbi, Mohammed Mahri, Tsute Chen

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: bacteria; bacteriome; carcinoma; microbiome; mouth; smokeless; snuff; tobacco

Online: 6 March 2017 (07:18:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0527.v1

Radiation Oncology Policy for Risk reduction from novel COVID-19 Pandemic in Radiation Oncology Department

Bushra Rana

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Radiation oncology; COVID-19; Radiation therapist COVID-19 policy; Radiation oncology departmental Policy

Online: 30 April 2020 (11:02:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0139.v1

Cancer: A Turbulence Problem

Abicumaran Uthamacumaran

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cancer; Turbulence; Navier-Stokes; Chaos; Complexity; Fractals; Fluid Dynamics; Reprogramming

Online: 14 February 2019 (14:04:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints201609.0074.v1

Regulation of ERK and AKT Pathways by Hepatitis B Virus X Protein via Notch1 Pathway in Hepatocellular Carcinoma

Bo Liao, Hong-Hao Zhou, Hui-Fang Liang, Chang-Hai Li

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: hepatocellular carcinoma; hepatitis B virus X protein; Notch1 pathway; ERK; AKT

Online: 21 September 2016 (09:49:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0188.v1

The Apoptosis Induction of Oleandrin on Osteosarcoma Cells through Regulating Mitochondrial- and Death Receptor-Dependent Apoptotic Pathways in Vitro

Yunlong Ma, Bin Zhu, Lei Yong, Chunyu Song, Xiao Liu, Huilei Yu, Peng Wang, Zhongjun Liu, Xiaoguang Liu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: oleandrin; osteosarcoma; apoptosis; caspases

Online: 22 August 2016 (05:35:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints201701.0094.v1

Theranostics in Nuclear Medicine Practice

Anna Yordanova, Elisabeth Eppard, Stefan Kürpig, Stefan Schönberger, Maria Gonzalez-Carmona, Georg Feldmann, Hojjat Ahmadzadehfar, Markus Essler

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: theranostics; nuclear medicine; personalized medicine

Online: 22 January 2017 (04:29:27 CET)

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Preprint REVIEW | doi:10.20944/preprints201807.0071.v1

The Role of Next-Generation Sequencing in Precision Medicine: A Review of Outcomes in Oncology

Margaret Morash, Hannah Mitchell, Himisha Beltran, Olivier Elemento, Jyotishman Pathak

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: precision medicine; next generation sequencing; oncology, patient outcomes; health insurance coverage

Online: 4 July 2018 (11:06:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0165.v1

Pueraria mirifica Exerts Estrogenic Effect and Promotes Mammary and Endometrial

Anna Kakehashi, Midori Yoshida, Yoshiyuki Tago, Naomi Ishii, Min Gi, Hideki Wanibuchi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Pueraria mirifica; mammary gland; uterus; carcinogenesis; estrogenic activity; Donryu rat

Online: 17 August 2016 (11:57:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0016.v1

Human Caveolin-1 a Potent Inhibitor for Prostate Cancer Therapy: A Computational Approach

Uzma Khanam, Pallavi Somvanshi, Shafiul Haque, Balwant Kishan Malik, Bhawna Rathi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: molecular dynamics simulation; virtual screening; molecular docking; prostate cancer; caveolin-1

Online: 7 October 2016 (12:09:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0105.v1

Comparison of Two EpCAM-Based Methods for CTC Detection and Molecular Characterization in Advanced Colorectal Cancer

Santiago Cabezas-Camarero, Virginia De La Orden, Silvia Veganzones-De-Castro, Beatriz Medievo-Valeros, Manuel Enrique Fuentes-Ferrer, Antonio Sánchez-Ruiz, Mariano Provencio, Enrique Aranda, Javier Sastre, Eduardo Díaz-Rubio

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: circulating tumor cells; CTC, liquid biopsy; KRAS; colorectal cancer; EpCAM; CellSearch; IsoFlux; castPCR; intratumor heterogeneity

Online: 21 November 2016 (09:52:20 CET)

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Preprint REVIEW | doi:10.20944/preprints202003.0201.v1

Oncogenic Signaling Pathways in Cancer: An Overview

Afshin Derakhshani, Zeinab Rostami, Sina Taefehshokr, Hossein Safarpour, Reza Vaezi Astamal, Nima Taefehshokr, Nazila Alizadeh, Antonella Argentiero, Nicola Silvestris, Behzad Baradaran

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer; cell signaling; therapeutic targets; signaling pathways

Online: 12 March 2020 (04:53:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0288.v1

Cancer: Strange Attractors and Complexity

Abicumaran Uthamacumaran

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cancer; Turbulence; Complexity; Machine Learning; Chaos; Reprogramming

Online: 27 June 2019 (11:36:18 CEST)

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Preprint EDITORIAL | doi:10.20944/preprints201608.0130.v1

What Is the Main Cause of Cancer?

Miguel López-Lázaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: carcinogenesis; cancer; age distribution of cancer

Online: 11 August 2016 (11:40:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0168.v1

A Noninvasive Comparison Study between Human Gliomas with IDH1 and IDH2 Mutations by MR Spectroscopy

Xin Shen, Natalie Voets, Sarah Larkin, Nick de Pennington, Richard Stacey, Puneet Plaha, James McCullagh, Christopher J Schofield, Stuart Clare, Peter Jezzard, Tom Cadoux-Hudson, Olaf Ansorge, Uzay Emir

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: glioma, isocitrate dehydrogenase, MR spectroscopy, metabolism, neurochemical profile

Online: 13 December 2018 (13:52:56 CET)

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Preprint COMMENTARY | doi:10.20944/preprints201608.0187.v1

A Plausible Biological Mechanism by which Extremely Low-Frequency Electromagnetic Fields Increase the Risk of Childhood Leukemia

Miguel López-Lázaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: magnetic fields; power lines; cancer; carcinogenesis; stem cell division theory of cancer

Online: 22 August 2016 (05:15:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0093.v1

Efficacy and Safety of Eribulin in Taxane-Refractory Patients in the “Real World”

Vito Lorusso, Saverio Cinieri, Agnese Latorre, Luca Porcu, Lucia Del Mastro, Fabio Puglisi, Sandro Barni

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: metastatic breast cancer; taxanes; eribulin; observational study

Online: 26 September 2016 (11:39:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201612.0107.v1

Evidence for the Involvement of Toll-Like Receptor 4 (TLR4)-Mediated Apoptosis in Gynecological Cancers

Jinyoung Won, Youngjeon Lee, Kyu-Tae Chang, Yonggeun Hong

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: apoptosis; gynecologic cancer; lipopolysaccharide; proliferation; Toll-like receptor

Online: 20 December 2016 (11:12:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints201701.0098.v1

Induction of G2M Arrest by Flavokawain A, A Kava Chalcone, Increases the Responsiveness of HER2 Overexpressing Breast Cancer Cells to Herceptin

Danielle D. Jandial, Lauren S. Krill, Lixia Chen, Chunli Wu, Yu Ke, Jun Xie, Bang H. Hoang, Xiaolin Zi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Flavokawain A; HER2 overexpression; resistance to apoptosis

Online: 23 January 2017 (03:30:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0098.v1

Adenovirus with DNA Packaging Gene Mutations Increased Virus Release

Stephen L. Wechman, Xiao-Mei Rao, Kelly M. McMasters, Heshan Sam Zhou

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: lung cancer; adenovirus; E1b; UV-irradiation; genomics

Online: 19 December 2016 (09:33:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0028.v1

Predictors of Survival in Children with Ependymoma from a Single Center: Using Random Survival Forests

Francisco H. C. Felix, Juvenia B. Fontenele

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: random survival forests; ependymoma; predictors; valproic acid

Online: 3 November 2016 (11:02:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0165.v2

Pueraria mirifica Exerts Estrogenic Effects in the Mammary Gland and Uterus and Promotes Mammary Carcinogenesis in Donryu Rats

Anna Kakehashi, Midori Yoshida, Yoshiyuki Tago, Naomi Ishii, Takahiro Okuno, Min Gi, Hideki Wanibuchi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Pueraria mirifica; mammary gland; uterus; carcinogenesis; estrogenic activity; Donryu rat

Online: 26 September 2016 (09:25:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0126.v3

IQGAP1 in Podosomes/Invadosomes Is Involved in the Progression of Glioblastoma Multiforme Depending on the Tumor Status

Deborah Rotoli, Natalia Pérez-Rodríguez, Manuel Morales, María Del Carmen Maeso, Julio Ávila, Ali Mobasheri, Pablo Martín-Vasallo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: IQGAP1; glioblastoma multiforme (GBM); scaffold protein; podosome/invadosome

Online: 16 January 2017 (10:30:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0906.v2

A Cancer-Specific Monoclonal Antibody against HER2 for Breast Cancers

Hiroyuki Suzuki, Mika K Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: HER2; cancer-specific monoclonal antibody; screening; epitope; flow cytometry

Online: 24 October 2023 (08:08:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201711.0082.v1

Spectroscopic Evidence, Evaluation of Biological Activity and Prediction of the Safety Profile of Fatty Hydroxamic Acids Derived from Olive Oil Triacylglycerides

Monika Barbarić, Dražen Vikić-Topić, Željko Marinić, Danijela Bakarić, Marijana Zovko Končić, Katarina Mišković Špoljarić, Mirela Baus Lončar, Milena Jadrijević-Mladar Takač

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: fatty hydroxamic acids; synthesis; spectroscopy; antioxidant activity; cytotoxic activity; biological targets; ADMET; safety profile

Online: 14 November 2017 (04:42:18 CET)

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Preprint REVIEW | doi:10.20944/preprints201902.0043.v1

HER2 Directed Antibody-Drug-Conjugates beyond T-DM1 in Breast Cancer

Gabriel Rinnerthaler, Simon Peter Gampenrieder, Richard Greil

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: ADC; HM2-MMAE; (vic-)trastuzumab duocarmazine; Trastuzumab deruxtecan; TAK-522; Trastuzumab emtansine; anti-HER2/PBD-MA; HER2 low; HER2-low; mode of action

Online: 4 February 2019 (17:01:31 CET)

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Preprint REVIEW | doi:10.20944/preprints201608.0115.v2

Targeted Cancer Therapy: Vital Oncogenes and a New Molecular Genetic Paradigm for Cancer Initiation Progression and Treatment

Rudolph E. Willis

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: oncogenes; oncogene addiction; carcinogenesis; transcription factor; cancer genome; gene fusion; cancer genetics; cancer stem cell; targeted cancer therapy; personalized medicine

Online: 14 September 2016 (08:30:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0216.v1

A Dysbiotic Mycobiome Dominated by Candida albicans is Identified within Oral Squamous Cell Carcinomas

Manosha Perera, Nezar Noor Al-hebshi, Irosha Perera, Deepak Ipe, Glen Ulett, David J. Speicher, Tsute Chen, Newell W. Johnson

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: 18S rRNA; fungi; mycobiome; carcinoma; High-Throughput Nucleotide Sequencing; microbiome; mouth; squamous cell

Online: 30 March 2017 (05:37:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints201610.0100.v1

The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins

Yasushi Taniguchi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: BET; bromodomain; histone acetylation; gene transcription; BET inhibitor

Online: 24 October 2016 (05:06:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints201612.0113.v1

Breast Cancer Brain Metastases: Clonal Evolution in Clinical Context

Jodi M. Saunus, Amy E. McCart Reed, Zhun Leong Lim, Sunil R. Lakhani

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer; brain metastases; clonal evolution; precision medicine; genomics; tumour microenvironment

Online: 22 December 2016 (09:57:33 CET)

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Working Paper ARTICLE

Mathematical Modelling of the Dynamics of Tumor Growth and its Optimal Control

Jannatun Irana Ira, Md. Shahidul Islam, Jagadis Chandra Misra, Md. Kamrujjaman

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Mathematical models; tumor growth; chemotherapy; diffusion; optimal control

Online: 5 July 2020 (16:39:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0024.v1

Inflammatory Bacteriome Featuring Fusobacterium nucleatum and Pseudomonas aeruginosa Identified in Association with Oral Squamous Cell Carcinoma

Nezar Noor Al-hebshi, Akram Thabet Nasher, Mohamed Yousef Maryoud, Husham E. Homeida, Tsute Chen, Ali Mohamed Idris, Newell W. Johnson

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: 16S rRNA; bacteria; bacteriome; carcinoma; High-Throughput Nucleotide Sequencing; microbiome; mouth; squamous cell

Online: 6 March 2017 (04:47:15 CET)

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Preprint REVIEW | doi:10.20944/preprints201702.0098.v1

MicroRNAs in the Communication between Cancer Associated Fibroblasts (CAF) and Cancer Cells

Maren Schoepp, Anda Jana Stroese, Joerg Haier

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: MicroRNA; cancer associated fibroblasts; cell-cell communication; transformation; epigenetic

Online: 28 February 2017 (10:29:27 CET)

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Preprint REVIEW | doi:10.20944/preprints202104.0602.v1

Biochemistry, Not Oncogenes, may Demystify and Defeat Cancer

Jay Kulsh

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer; DNA sequencing; DNA synthesis; enzyme; free-radicals; genome; HPV; oncogenes; retinoblastoma; ribonucleotide reductase; RnR; SMT; TCGA

Online: 22 April 2021 (09:37:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints201909.0304.v1

A Complex Systems Analysis of Cancer Networks

Abicumaran Uthamacumaran

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer; complexity; machine learning; deep learning; fluid dynamics; turbulence; chaos

Online: 27 September 2019 (07:24:43 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints201906.0079.v1

Chemokines are Underestimated in Preventing the Metastasizing and the Immune Elimination of Ovarian Cancer

Ruurd Torensma, Petra Zusterzeel

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: ovarian cancer metastasis, chemokines, cytoreductive surgery, Cytotoxic T cells, BDCA3 Dendritic cells.

Online: 10 June 2019 (16:03:23 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202403.1661.v2

A Case Report of Acute Lymphoblastic Leukaemia (ALL)/Lymphoblastic Lymphoma (LBL) Following the Second Dose of Comirnaty®: An Analysis of the Potential Pathogenic Mechanism Based on of the Existing Literature

Patrizia Gentilini, Janci C. Lindsay, Nafuko Konishi, Masanori Fukushima, Panagis Polykretis

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: COVID-19 genetic vaccines; mRNA vaccines; adverse effects; lymphoblastic leukemia; lymphoblastic lymphoma

Online: 1 April 2024 (13:21:50 CEST)

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In this report we describe the case of a healthy, young, athletic woman who developed acute lymphoblastic leukaemia (ALL)/lymphoblastic lymphoma (LBL) after receiving the second dose of the Pfizer/BioNTech modified mRNA (modRNA) COVID-19 genetic vaccine (marketed as Comirnaty^®). The first dose of the genetic vaccine did not appear to illicit any noticeable side effects, but within 24 hours of the second dose the patient suffered widespread and intensifying bone pain, fever, vomiting, and general malaise. Due to the persistence of the symptoms, the patient underwent a series of tests and examinations including a full laboratory workup, a consult with a clinical immunologist and rheumatologist, a Positron Emission Tomography (PET) imaging, as well as an osteomedullary biopsy. These together led to a definitive diagnosis of ALL. A time interval of 16 weeks from the second vaccination to the diagnosis of cancer was noted. Several similar cases with identical pathology which developed after the modRNA COVID-19 vaccination, are described in case reports in the scientific literature. The massive and indiscriminate use of genetic vaccines to fight COVID-19 is raising serious concerns about their safety and about the technology platform as a whole for this purpose. Growing evidence is accumulating regarding the biodistribution and persistence of the modRNA which can reach, thanks to the lipid nanoparticles, a multitude of tissues and organs of the body, including the bone marrow and other blood-forming organs and tissues. Moreover, there is evidence that the modRNA vaccines display a particular tropism for the bone marrow, influencing the immune system at multiple levels and being able to trigger not only autoimmune-based pathologies, but also neoplastic mechanisms. The aim of this article is to assess, on the basis of the available scientific literature, the risk of developing haematopoietic cancers after modRNA vaccination, and to investigate the potential genetic mechanisms involved in the pathogenesis of disease.

Preprint ARTICLE | doi:10.20944/preprints202309.0906.v5

Establishment of a Novel Cancer-Specific Anti-HER2 Monoclonal Antibody H2Mab-250/H2CasMab-2 for Breast Cancers

Mika K Kaneko, Hiroyuki Suzuki, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: HER2; cancer-specific monoclonal antibody; screening; epitope; flow cytometry

Online: 4 January 2024 (11:30:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0051.v1

TTF1, in the Form of Nanoparticles, Inhibits Angiogenesis, Cell Migration and Cell Invasion in VitroandIn Vivoin Human Hepatoma through STAT3 Regulation

Bin Xiao, Dongjing Lin, Xuan Zhang, Meilan Zhang, Xuewu Zhang

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: angiogenesis; cell invasion; cell migration; Flavone derivative (TTF1); hepatoma; STAT3

Online: 9 November 2016 (10:21:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0080.v1

Detecting Breast Cancer with a Dual-Modality Device

Kamila Padia, Tania S. Douglas, Lydia L. Cairncross, Roland V. Baasch, Christopher L. Vaughan

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer; dense breasts; dual-modality imaging; FFDM; ABUS

Online: 14 March 2017 (09:24:58 CET)

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Preprint REVIEW | doi:10.20944/preprints201703.0052.v1

Oral Mucositis: Melatonin Gel an Effective New Treatment

Ahmed E Abdel-Moneim, Ana Guerra-Librero, Javier Florido, Ying-Qiang Shen, Beatriz Fernández-Gil, Darío Acuña-Castroviejo, Germaine Escames

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: mucositis; radiotherapy; chemotherapy; pathophysiology; management; melatonin

Online: 9 March 2017 (04:46:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0126.v1

IQGAP1 in Podosome /Invadosome is Involved in the Progression of Glioblastoma Multiforme Depending on the Tumor Status

Deborah Rotoli, Natalia Pérez-Rodríguez, Manuel Morales, María Del Carmen Maeso, Julio Ávila, Ali Mobasheri, Pablo Martín-Vasallo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: IQGAP1; GBM; scaffold protein; podosome/invadosome

Online: 24 November 2016 (18:02:20 CET)

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Preprint REVIEW | doi:10.20944/preprints201707.0074.v1

The Stem Cell Division Theory of Cancer

Miguel López-Lázaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer etiology; carcinogenesis; cancer prevention; stem cells; cancer stem cells; stem cell environment; cells of origin in cancer; somatic mutation theory of cancer

Online: 26 July 2017 (08:42:41 CEST)

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All cancer registries constantly show striking differences in cancer incidence by age and among tissues. For example, lung cancer is diagnosed hundreds of times more often at age 70 than at age 20, and this cancer in nonsmokers occurs thousands of times more frequently than heart cancer in smokers. An analysis of these differences using basic concepts in cell biology indicates that cancer is the end-result of the accumulation of cell divisions in stem cells. In other words, the main determinant of carcinogenesis is the number of cell divisions that the DNA of a stem cell has accumulated in any type of cell from the zygote. Cell division, process by which a cell copies and separates its cellular components to finally split into two cells, is necessary to produce the large number of cells required for living. However, cell division can lead to a variety of cancer-promoting errors, such as mutations occurring during DNA replication, chromosome aberrations arising during mitosis, errors in the distribution of cell-fate determinants between the daughter cells, and failures to restore physical interactions with other tissue components. Some of these errors are spontaneous, others are promoted by endogenous DNA damage occurring during quiescence, and others are influenced by pathological and environmental factors. The cell divisions required for carcinogenesis are primarily caused by multiple local and systemic physiological signals rather than by errors in the DNA of the cells. As carcinogenesis progresses, the accumulation of DNA errors promotes cell division and eventually triggers cell division under permissive extracellular environments. The accumulation of cell divisions in stem cells drives not only the accumulation of the DNA alterations required for carcinogenesis, but also the formation and growth of the abnormal cell populations that characterize the disease. This model of carcinogenesis provides a new framework for understanding the disease and has important implications for cancer prevention and therapy.

Preprint ARTICLE | doi:10.20944/preprints201902.0011.v1

Eradicating Metastatic Cancer and the Evolutionary Dynamics of Extinction

Robert Gatenby, Joel S. Brown

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cancer treatment, resistance to treatment, evolution of resistance, background extinctions

Online: 1 February 2019 (10:29:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints201704.0142.v1

Retrospective Proteomic Screening of 100 Breast Cancer Tissues

Ida Pucci-Minafra, Gianluca Di Cara, Rosa Musso, Patrizia Cancemi, Nadia Ninfa Albanese, Elena Roz, Salvatore Minafra

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer; surgical tissues; gel-based proteomics; mass spectrometry; protein clustering

Online: 24 April 2017 (05:14:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0906.v1

A Cancer-Specific Monoclonal Antibody against HER2 for Breast Cancers

Hiroyuki Suzuki, Mika K Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: HER2; cancer-specific monoclonal antibody; screening; epitope; flow cytometry

Online: 14 September 2023 (05:00:22 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202003.0350.v1

A Radiation Oncology Departmental Policy for the 2019 Novel Coronavirus (COVID-19) Pandemic

Yuan James Rao, Destie Provenzano, Hiram A. Gay, Paul W. Read, Martin Ojong, Sharad Goyal

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: COVID-19; SARS-CoV-2; coronavirus; novel coronavirus; department policy; radiation oncology

Online: 23 March 2020 (09:55:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0906.v3

Establishment of a Novel Cancer-Specific Anti-HER2 Monoclonal Antibody H2Mab-250/H2CasMab-2 for Breast Cancers

Mika K Kaneko, Hiroyuki Suzuki, Tomokazu Ohishi, Tomohiro Tanaka, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: HER2; cancer-specific monoclonal antibody; screening; epitope; flow cytometry

Online: 28 November 2023 (03:35:30 CET)

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Preprint REVIEW | doi:10.20944/preprints201611.0120.v1

Pancreatic Neuroendocrine Neoplasms: Basic Biology, Current Treatment Strategies and Prospects for the Future

Akihiro Ohmoto, Hirofumi Rokutan, Shinichi Yachida

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: pNENs; 2010 WHO classification; Ki-67 index; mitotic count; pNEC; tumor differentiation; whole-exome sequence data; everolimus; sunitinib; platinum regimen

Online: 24 November 2016 (10:59:33 CET)

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Preprint ARTICLE | doi:10.3390/sci2020024

SOX2OT Long Noncoding RNA Is Regulated by the UPR in Oestrogen Receptor-Positive Breast Cancer

Carole Ferraro-Peyret, Marjan Askarian-Amiri, Debina Sarkar, Wayne Joseph, Herah Hansji, Bruce Baguley, Euphemia Leung

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer; LncRNA; SOX2OT; SOX2; UPR; 4-OH tamoxifen

Online: 6 April 2020 (00:00:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0044.v1

Alcohol-containing Mouthwashes and Oral Cancer: A Mechanistic Explanation

José Manuel Calderón-Montaño, Julio José Jiménez-Alonso, Emilio Guillén-Mancina, Estefanía Burgos-Morón, Miguel Lopez-Lazaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer prevention; carcinogenesis; oral cancer; pharynx cancer; mouthrinses; ethanol.

Online: 6 March 2018 (14:28:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0906.v4

Establishment of a Novel Cancer-Specific Anti-HER2 Monoclonal Antibody H2Mab-250/H2CasMab-2 for Breast Cancers

Mika K Kaneko, Hiroyuki Suzuki, Tomokazu Ohishi, Tomohiro Tanaka, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: HER2; cancer-specific monoclonal antibody; screening; epitope; flow cytometry

Online: 28 December 2023 (02:42:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0190.v1

Synthesis and Preliminarily Cytotoxicity to A549, HCT116 and MCF-7 Cell Lines of Thieno[2,3-d]pyrimidine Derivatives Containing Isoxazole Moiety

Jianping Yong, Canzhong Lu, Xiaoyuan Wu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Isoxazole moiety; Thieno[2,3-d]pyrimidine derivatives; Synthesis; Anticancer activity

Online: 24 March 2017 (17:52:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints201908.0118.v1

Green Synthesis of Silver Nanoparticles Using Scindapsus officinalis (Gajpipli): In-Vitro Cytotoxic Activity Against HepG-2 & MCF-7 Cancer Cell Lines

Manish Pathak, Vikas Kumar, Prateek Pathak, Rahul Majee, Promod W. Ramteke, Amita Verma

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Silver nanoparticles, Scindapsus officinalis, MTT assay, HepG-2, MCF-7

Online: 13 August 2019 (09:10:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0126.v2

IQGAP1 in Podosome /Invadosome is Involved in the Progression of Glioblastoma Multiforme Depending on the Tumor Status

Deborah Rotoli, Natalia Dolores Pérez-Rodríguez, Manuel Morales, María del Carmen Maeso, Julio Ávila, Ali Mobasheri, Pablo Martín-Vasallo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: IQGAP1; GBM; scaffold protein; podosome/invadosome

Online: 9 January 2017 (03:21:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0215.v1

Discovery and Biological Evaluation of a Series of Pyrrolo[2,3-b]pyrazines as Novel FGFR Inhibitors

zhang yan, Hongchun Liu, Zhen Zhang, Ruifeng Wang, Tongchao Liu, Chaoyun Wang, Yuchi Ma, Jing Ai, Dongmei Zhao, Jingkang Shen, Bing Xiong

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: FGFR1; inhibitor; kinase inhibitor; pyrazine; hinge binder

Online: 30 March 2017 (04:13:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201708.0023.v1

CBFA2T2 is Associated with a Cancer Stem Cell State in Renal Cell Carcinoma

Du-Chu Chen, You-de Liang, Yi-Ze Wang, Chun-Zhi Ai, Xin-Xing Zhu, Ya-Wei Yan, yasmeen saeed, Bin Yu, Jingying huang, Yuxin Gao, Jiaqi Liu, Yi-zhou jiang, Min Liu, Demeng Chen

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: CBFA2T2; renal cell carcinoma; cancer stem cells; OCT-4; NANOG

Online: 7 August 2017 (15:22:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0102.v1

Novel Combination of Withaferin A and Sulforaphane Inhibits Epigenetic Machinery, Cellular Viability and Induces Apoptosis of Breast Cancer Cells

Kendra Royston, Neha Udayakumar, Kayla Lewis, Trygve Tollefsbol

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: sulforaphane; withaferin; breast cancer; HDAC1; DNMTs; chemoprevention; epigenetics

Online: 12 May 2017 (05:19:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0315.v1

p53 Reaction to Cellular Stress Maximizes Apoptosis in Glioblastoma

Cheng-Jung Ho, Yu-Hsuan Pao, Hsin-Wen Chen, Wei-Hua Zhu, Ru-Wei Lin, Cheng wei Chu, Joon Khim Loh, Yi-Ren Hong, Chihuei Wang

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: glioblastoma; p53; apoptosis; doxorubicin; bortezomib; vorinostat.

Online: 30 January 2019 (13:03:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0018.v1

PKM2 Knockdown Induces Autophagic Cell Death via the AKT/mTOR Pathway in Human Prostate Cancer Cells

Prasanta Dey, Amit Kundu, Richa Sachan, Jaehyun Park, Mee Young Ahn, Kyungsil Yoon, Jaewon Lee, Nam Deuk Kim, In Su Kim, Byung Mu Lee, Hyung Sik Kim

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: pyruvate kinase M2; prostate cancer; cancer metabolism; mTOR; autophagy

Online: 3 January 2019 (12:32:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints201708.0103.v1

Cancer Etiology: Variation in Cancer Risk among Tissues is Poorly Explained by the Number of Gene Mutations

Miguel Lopez-Lazaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: stem cells; somatic mutations; cancer prevention; carcinogenesis; whole genome sequencing; stem cell division theory of cancer; bad luck of cancer

Online: 30 August 2017 (12:14:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201706.0097.v1

Indirubin inhibits cell proliferation, migration, invasion andangiogenesis in tumor-derived endothelial cells

Li zhuohong, Zhu chaofu, An baiping, Chen yu, He xinyue, Qian Lin, Lan lan, Shijie Li

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Indirubin; Td-EC; proliferation; migration; invasion; angiogenesis

Online: 20 June 2017 (11:30:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202102.0150.v1

CTLA-4 in Regulatory T Cells for Cancer Immunotherapy

Navid Sobhani, Dana Rae Tardiel-Cyril, Aram Davtyan, Daniele Generali, Raheleh Roudi, Yong Li

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: CTLA-4; Treg cells: Immune checkpoint inhibitors; CD28; Antigen Presenting Cells

Online: 5 February 2021 (09:35:47 CET)

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Preprint REVIEW | doi:10.20944/preprints201809.0351.v3

Organogenesis: A New Theme to Study Genetic Expression in Adult Liver Regeneration After Partial Hepatectomy

Haydar Witwit

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: organogenesis, adult liver, translational, regeneration, homeobox, hox, Wnts, growth factors, theme, gene expression, cancer, hepatectomy, three-dimensional, organoid

Online: 16 January 2019 (09:14:06 CET)

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Preprint REVIEW | doi:10.20944/preprints201705.0108.v1

Long-Lived Epidermal Cancer-Initiating Cells

Marina Youssef, Andrew Cuddihy, Charbel Darido

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: squamous cell carcinoma (SCC), Grainyhead-like 3 (Grhl3), interfollicular epidermis (IFE), supra-basal epidermis, involucrin (IVL), cancer-initiating cell (CIC), cancer stem cell (CSC).

Online: 12 May 2017 (18:15:31 CEST)

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Non-melanomatous skin cancers (NMSCs), which include basal and squamous cell carcinoma (BCC and SCC respectively), represent a significant burden on the population as well as an economic load to the health care system, yet treatments of these preventable cancers remain ineffective. Although primary prevention is possible through minimising sunlight exposure, the World Health Organisation estimates that between 2 and 3 million new cases of NMSCs are diagnosed each year, accounting for 1 in 3 of all newly diagnosed cancers. Furthermore, studies have estimated there has been a 2-fold increase in the incidence of NMSCs between 1960s and 1980s. The increase in cases of NMSCs as well as the lack of effective treatments makes the need for novel therapeutic approaches all the more necessary. To rationally develop more targeted treatments for NMSCs, a better understanding of the cell of origin, in addition to the underlying pathophysiological mechanisms that govern the development of these cancers, is urgent. NMSCs are generally thought to arise from specific types of stem cells that become the source of clonal expansion of tumourigenic cells. Previous research on SCC has alluded to these stem cells being localised in the basal compartment of the skin, which ordinarily houses the progenitor cells that contribute towards wound healing and normal cell turnover of overlying epidermal skin layers. More recent research has suggested that commitment to differentiation, which requires exiting the basal, progenitor-cell compartment, is a reversible mechanism. Genetic modifications engage differentiated cells into dedifferentiation, converting them into cancer-initiating cells (CICs) and thereby promoting a tumourigenic environment. Here we explore the most recent developments in the understanding of skin SCC cell of origin, and discuss a case study illustrating the loss of the Grainy-head like 3 (GRHL3) transcription factor in suprabasal layers, which confers a tendency towards tumour development and thereby challenging the “stem cell” theory of tumourigenesis.

Preprint ARTICLE | doi:10.20944/preprints202102.0216.v1

The Planckian Distribution Equation As A Novel Method To Predict The Efficacy Of Breast Cancer Pharmacotherapy

Shreshth Rajan

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Planckian Distribution Equation; breast cancer; mRNA; chemotherapy

Online: 8 February 2021 (16:00:22 CET)

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Preprint REVIEW | doi:10.20944/preprints201608.0115.v1

Targeted Cancer Therapy: Vital Oncogenes and a New Molecular Genetic Paradigm for Cancer Initiation Progression and Treatment

Rudolph E. Willis

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: oncogenes; oncogene addiction; carcinogenesis; transcription factor; cancer genome; gene fusion; cancer genetics; cancer stem cell; targeted cancer therapy; personalized medicine

Online: 11 August 2016 (11:04:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0155.v1

Prognostic Significance of EIF4G1 in Patients with Pancreatic Ductal Adenocarcinoma

Tae Sik Goh, Mihyang Ha, Jung Sub Lee, Dae Cheon Jeong, Eun Sang Jung, Myoung-Eun Han, Yun Hak Kim, Sae-Ock Oh

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: EIF4GI; pancreatic ductal adenocarcinoma; prognosis; GEO; TCGA

Online: 16 January 2019 (07:54:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints201804.0082.v1

Mitochondrial Dysfunction and Cytochrome C Translocation Induced by Resveratrol Are Dependent on NF-κB Activity and Facilitate TRAIL Sensitivity in Human Lung Cancers

Mohammad Rasheduzzaman, Jae-Kyo Jeong, Sang-Youel Park

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Resveratrol; autophagy; TRAIL; apoptosis; lung cancer cells; NF-κB; Cytochrome c

Online: 6 April 2018 (18:59:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0340.v1

Effects of Light Dosimetry in Photobleaching of The Photosensitizer (PS) and Cyanine Dye (CD) Moieties in Ps-Cd Conjudates and Its Correlation with Photodynamic Therapy (PDT) Efficacy

Nadine James, Ravindra R. Cheruku, Joseph R. Missert, Ulas Sunar, Ravindra K. Pandey

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: photodynamic therapy; photobleaching; photosensitizers; fluorescence imaging

Online: 24 May 2018 (08:32:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0221.v1

Does Giant Cell Glioblastoma Have a Better Prognosis in Comparison to Glioblastoma Multiform? A Secondary Analysis of the SEER Database from 1985–2014

Amro K. Bin Abdulrahman, Yousef R. Bukhari, Abdulaziz M. Faqihi, Khalid A. Bin Abdulrahman, Juan Gabriel Ruiz

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: brain cancer; glioblastoma multiforme; giant cell glioblastoma; prognosis

Online: 17 May 2019 (08:40:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0236.v1

Prostate-Derived ETS Factor (PDEF) Regulates Yes Associated Protein 1 (YAP1) in Prostate Cancer Cells: A Potential Cross-Talk between PDEF and Hippo Signaling

Praveen Kumar Jaiswal, Suman Mohajan, Sweaty Koul, Fengtian Wang, Runhua Shi, Hari K. Koul

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: YAP1; PDEF; prostate cancer

Online: 20 October 2019 (16:18:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0238.v1

Identification of Potent Inhibitors against Aurora Kinase A Using Molecular Docking and Molecular Dynamics Simulation Studies

Sathishkumar Chinnasamy, Gurudeeban Selvaraj, Aman Chandra Kaushik, Satyavani Kaliamurthi, Asma Sindhoo Nangraj, Chandrabose Selvaraj, Sanjeev Kumar Singh, Ramanathan Thirugnanasambandam, Keren Gu, Donq-qing Wei

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: aurora kinase A; molecular docking; DFT; MD simulation

Online: 23 August 2019 (05:01:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0079.v1

Dietary Intake of Meat Cooking-Related Mutagens (HCAs) and Risk of Colorectal Adenoma and Cancer: A Systematic Review and Meta-Analysis

Manuela Chiavarini, Gaia Bertarelli, Liliana Minelli, Roberto Fabiani

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: heterocyclic amines (HCAs); meat intake; colorectal cancer; colorectal adenomas; cancer prevention

Online: 9 May 2017 (06:13:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0109.v1

Insight into the Role and Regulation of Gap Junction Genes in Lung Cancer and Identification of Nuclear Cx43 as a Putative Biomarker of Poor Prognosis

Trond Aasen, Irene Sansano, Maria Ángeles Montero, Cleofé Romagosa, Jordi Temprana-Salvador, Alexandre Martínez-Marti, Teresa Moliné, Javier Hernández-Losa, Santiago Ramón y Cajal

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: connexins; Cx43; gap junctions; lung cancer; immunohistochemistry; prognosis; nuclear

Online: 13 February 2019 (10:30:49 CET)

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Direct intercellular communication, mediated by gap junctions formed by the connexin transmembrane protein family, is frequently dysregulated in cancer. Connexins have been described as tumour suppressors, but emerging evidence suggests that they can also act as tumour promoters. This feature is connexin- and tissue-specific and may be mediated by complex signalling pathways through gap junctions or hemichannels or by completely junction-independent events. Lung cancer is the number one cancer in terms of mortality worldwide, and novel biomarkers and therapeutic targets are urgently needed. Our objective was to gain a better understanding of connexins in this setting. We used several in silico tools to analyse TCGA data in order to compare connexin mRNA expression between healthy lung tissue and lung tumours and correlated these results with gene methylation patterns. Using Kaplan-Meier plotter tools, we analysed a microarray dataset and an RNA-seq dataset of non-small cell lung tumours in order to correlate connexin expression with patient prognosis. We found that connexin mRNA expression is frequently either upregulated or downregulated in lung tumours. This correlated with both good and poor prognosis (overall survival) in a clear connexin isoform-dependent manner. These associations were strongly influenced by the histological subtype (adenocarcinoma versus squamous cell carcinoma). We present an overview of all connexins but particularly focus on four isoforms implicated in lung cancer: Cx26, Cx30.3, Cx32 and Cx43. We further analysed the protein expression and localization of Cx43 in a series of 72 human lung tumours. We identified a subset of tumours that exhibited a unique strong nuclear Cx43 expression pattern that predicted worse overall survival (p=0.014). Upon sub-stratification, the prognostic value remained highly significant in the adenocarcinoma subtype (p=0.002) but not in the squamous carcinoma subtype (p=0.578). This finding highlights the importance of analysis of connexin expression at the protein level, particularly the subcellular localization. Elucidation of the underlying pathways regulating Cx43 localization may provide for novel therapeutic opportunities.

Preprint ARTICLE | doi:10.3390/sci2020043

Differentiation of Heterogeneous Mouse Liver from HCC by Hyperpolarized <sup>13</sup>C Magnetic Resonance

Naama Lev-Cohain, Gal Sapir, Sivaranjan Uppala, Atara Nardi-Schreiber, Shraga Goldberg, Yael Adler-Levy, Jacob Sosna, J. Gomori, Rachel Katz-Brull

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: lactate dehydrogenase; alanine transaminase; MDR2 knockout; dissolution dynamic nuclear polarization; perfused precision cut liver slices

Online: 10 June 2020 (00:00:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0217.v1

Prevention of Cervical Cancer in Sub-Saharan Africa: the Promises and Challenges of HPV Vaccination

Eleanor Black, Robyn Richmond

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cervical cancer; HPV vaccination; sub-Saharan Africa

Online: 12 July 2018 (14:32:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0046.v1

Tumor Transcriptome in Patients with Lower Pectoralis Muscle Area Reveals IL-8 as a Prognostic Biomarker in Non-Small Cell Lung Cancer

Sarah Santiloni Cury, Diogo de Moraes, Paula Paccielli Freire, Grasieli de Oliveira, Douglas Venâncio Pereira Marques, Geysson Javier Fernandez, Maeli Dal-Pai-Silva, Érica Nishida Hasimoto, Patricia Pintor dos Reis, Silvia Regina Rogatto, Robson Francisco Carvalho

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: secretome; computed tomography; interleukin-8; tumor-derived factor; C2C12 cells; Cachexia

Online: 3 July 2019 (06:41:42 CEST)

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Preprint COMMENTARY | doi:10.3390/sci2020042

Advancing Therapies for Cancer—From Mustard Gas to CAR T

Dillon Jarrell, Seth Drake, Mark Brown

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: small molecule inhibitor; personalized medicine; precision medicine; oncology; targeted therapy; drug delivery; drug screening; chemotherapy

Online: 10 June 2020 (00:00:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints201801.0167.v1

Molecular imaging modalities using nanoprobes for cancer diagnosis

Daryoush Shahbazi-Gahrouei, Pegah Moradi Khaniabadi, Bita Moradi khaniabadi, Saghar Shahbazi-Gahrouei, Mona Fazel

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: molecular imaging; nanoparticles; cancer diagnosis; imaging modalities

Online: 18 January 2018 (05:12:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0546.v1

Atezolizumab and Pembrolizumab in Triple-Negative Breast Cancer: A Meta-Analysis

Mahwish Amin, Shaiza Sharif, Waleed Asghar, Humaira Sadaf, Azza Sarfraz, Zouina Sarfraz, Ivan Cherrez-Ojeda

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: triple negative breast cancer; Pembrolizumab; Atezolizumab; chemotherapy; anti-PD-L1; biomarkers; targeted therapies; development of novel drugs

Online: 24 May 2021 (09:23:50 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202403.1661.v1

A Case Report of Acute Lymphoblastic Leukaemia (ALL)/Lymphoblastic Lymphoma (LBL) Following the Second Dose of Comirnaty®: An Analysis of the Potential Pathogenic Mechanism Based on of the Existing Literature

Patrizia Gentilini, Janci C. Lindsay, Nafuko Konishi, Masanori Fukushima, Panagis Polykretis

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: COVID-19 genetic vaccines; mRNA vaccines; adverse effects; lymphoblastic leukemia; lymphoblastic lymphoma

Online: 27 March 2024 (08:34:34 CET)

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In this report we describe the case of a healthy, young, athletic woman who developed acute lymphoblastic leukaemia (ALL)/lymphoblastic lymphoma (LBL) after receiving the second dose of the Pfizer/BioNTech modified mRNA (modRNA) COVID-19 genetic vaccine (marketed as Comirnaty^®). The first dose of the genetic vaccine did not appear to illicit any noticeable side effects, but within 24 hours of the second dose the patient suffered widespread and intensifying bone pain, fever, vomiting, and general malaise. Due to the persistence of the symptoms, the patient underwent a series of tests and examinations including a full laboratory workup, a consult with a clinical immunologist and rheumatologist, a Positron Emission Tomography (PET) imaging, as well as an osteomedullary biopsy. These together led to a definitive diagnosis of ALL. A time interval of 16 weeks from the second vaccination to the diagnosis of cancer was noted. Several similar cases with identical pathology which developed after the modRNA COVID-19 vaccination, are described in case reports in the scientific literature. The massive and indiscriminate use of genetic vaccines to fight COVID-19 is raising serious concerns about their safety and about the technology platform as a whole for this purpose. Growing evidence is accumulating regarding the biodistribution and persistence of the modRNA which can reach, thanks to the lipid nanoparticles, a multitude of tissues and organs of the body, including the bone marrow and other blood-forming organs and tissues. Moreover, there is evidence that the modRNA vaccines display a particular tropism for the bone marrow, influencing the immune system at multiple levels and being able to trigger not only autoimmune-based pathologies, but also neoplastic mechanisms. The aim of this article is to assess, on the basis of the available scientific literature, the risk of developing haematopoietic cancers after modRNA vaccination, and to investigate the potential genetic mechanisms involved in the pathogenesis of disease.

Preprint REVIEW | doi:10.20944/preprints202004.0236.v1

Alternative Multidisciplinary Management Options for Locally Advanced Non-Small Cell Lung Cancer During the COVID-19 Global Pandemic

Sameera Kumar, Steven Chmura, Clifford Robinson, Steven H. Lin, Shirish M. Gadgeel, Jessica Donington, Josephine Feliciano, Thomas E. Stinchcombe, Maria Werner-Wasik, Martin J. Edelman, Drew Moghanaki

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: non-small cell lung cancer; locally advanced; COVID; SARS-CoV-2

Online: 15 April 2020 (09:50:21 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202211.0211.v1

An Oncospace for Human Cancers

Guim Aguadé-Gorgorió, José Costa, Ricard Solé

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer morphospace; microenvironmental complexity; genome instability; developmental abnormalities

Online: 11 November 2022 (03:18:06 CET)

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Preprint REVIEW | doi:10.20944/preprints202105.0376.v1

Gene Editing and Gene Therapy: Entering Uncharted Territory in Veterinary Oncology

Wesley Wierson, Alex Abel, Elizabeth Siegler, Stephen Ekker, Chad Johannes, Saad Kenderian, Jonathan Mochel

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Gene Editing; Gene Therapy; Oncology; Comparative Medicine; One Health

Online: 17 May 2021 (09:45:43 CEST)

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With rapid advances in gene editing and gene therapy technologies, the development of genetic, cell, or protein-based cures to disease are no longer the realm of science fiction but that of today’s practice. The impact of these technologies are rapidly bringing them to the veterinary market as both enhanced therapeutics and towards modeling their outcomes for translational application. Simply put, gene editing enables scientists to modify an organism’s DNA a priori through the use of site-specific DNA targeting tools like clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9 (CRISPR/Cas9). Gene therapy is a broader definition that encompasses the addition of exogenous genetic materials into specific cells to correct a genetic defect. More precisely, the U.S Food and Drug Administration (FDA) defines gene therapy as “a technique that modifies a person’s genes to treat or cure disease” by either (i) replacing a disease-causing gene with a healthy copy of the gene; (ii) inactivating a disease-causing gene that was not functioning properly; or (iii) introducing a new or modified gene into the body to help treat a disease. In some instances, this can be accomplished through direct transfer of DNA or RNA into target cells of interest or more broadly through gene editing. While gene therapy is possible through the simple addition of genetic information into cells of interest, gene editing allows the genome to be reprogrammed intentionally through the deletion of diseased alleles, reconstitution of wild type sequence, or targeted integration of exogenous DNA to impart new function. Cells can be removed from the body, altered, and reinfused, or edited in vivo. Indeed, manufacturing and production efficiencies in gene editing and gene therapy in the 21^st century has brought the therapeutic potential of in vitro and in vivo reprogrammed cells, to the front lines of therapeutic intervention (Brooks et al., 2016). For example, CAR-T cell therapy is revolutionizing hematologic cancer care in humans and is being translated to canines by us and others, and gene therapy trials are ongoing for mitral valve disease in dogs.

Preprint ARTICLE | doi:10.20944/preprints201705.0186.v2

Residence in proximity of a coal-oil-fired thermal power plant and risk of lung and bladder cancer in north-eastern Italy. A population-based study, 1995-2009

Paolo Collarile, Ettore Bidoli, Fabio Barbone, Loris Zanier, Stefania Del Zotto, Simonetta Fuser, Fulvio Stel, Chiara Panato, Irene Gallai, Diego Serraino

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Air pollution; coal-fired thermal power plant; oil thermal power plant; geocoded; lung cancer; bladder cancer; North-eastern Italy

Online: 20 June 2017 (08:50:26 CEST)

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Working Paper ARTICLE

Lung Adenocarcinoma Patients Own Higher Risk of SARS-CoV-2 Infection

Long Chen, Li Zhong

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: lung adenocarcinoma; SARS-CoV-2; ACE2; miR-125b-5p; IL6

Online: 26 February 2020 (02:50:17 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints201810.0689.v1

Augmentation of 5-aminolevulinic Acid Treatment of Glioblastoma by Adding Ciprofloxacin, Deferiprone, 5-fluorouracil and Febuxostat: The CAALA Regimen

Richard Kast, Nicolas Skuli, Iacopo Sardi, Felix Capanni, Martin Hessling, Guido Frosina, Anton Kast, Georg Karpel-Massler, Marc-Eric Halatsch

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: 5-aminolevulinic acid, ciprofloxacin, deferiprone, fluorescence, 5-fluorouracil, febuxostat, glioblastoma, photodynamic treatment, temozolomide,

Online: 29 October 2018 (14:12:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints201710.0157.v1

Docosahexaenoic Acid Induces Cell Death through Downregulation of Hedgehog Signaling via Surt6 Activation in Human EGFR Mutant Non-Small Cell Lung Cancer

Soyeon Jeong, Kaipeng Jing, Soyeon Shin, Soyeon Kim, Seung-Hyeon Han, Yoon-Seon Yoo, Young-Joo Jeon, Jun-Young Heo, Gi-Ryang Kweon, Seung-Kiel Park, Jong-Il Park, Kyu Lim

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: docosahexaenoic acid; apoptosis; SIRT6; Hedgehog signaling; non-small cell lung cancer cells

Online: 24 October 2017 (05:43:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0229.v6

Lipofuscin as the Main Driving Force of Current Age-Related Disease: Justification and Strategies for Removal

Michael Renteln

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Anti-aging therapy; lipofuscin; SENS; TFEB; telomerase; and intracellular microbes

Online: 20 March 2023 (03:43:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints201802.0091.v1

Screening for Selective Anticancer Activity of Plants from Grazalema Natural Park, Spain

José Manuel Calderón-Montaño, Sara María Martínez-Sánchez, Estefanía Burgos-Morón, Emilio Guillén-Mancina, Julio José Jiménez-Alonso, Felipe García, Abelardo Aparicio, Miguel López-Lázaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer; lung cancer; leukemia; Daphne; Thapsia; daphnane diterpenes

Online: 13 February 2018 (07:08:47 CET)

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Preprint REVIEW | doi:10.20944/preprints202104.0517.v1

Overview of Adverse Events Associated With Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy

Ekaterina Vorozheikina, Magdalena Ruiz, Maria Leticia Solari, Dmitry Ostasevich, Luis Mendoza

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: CAR T-cells; chimeric antigen receptor T cells; cytokine release syndrome; central nervous system toxicity; neurotoxicity; adverse events; pathophysiology

Online: 19 April 2021 (21:17:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202201.0372.v1

Non-Viral Gene Therapy Vectors for Cancer Treatment

Shrey Kanvinde, Tanmay Kulkarni, Suyash Deodhar, Deep Bhattacharya, Aneesha Dasgupta

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: gene therapy; non-viral vectors; gene delivery; cancer; nucleic acid delivery; nanoparticles; lipids; lipid nanoparticles; mRNA; siRNA

Online: 25 January 2022 (09:01:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0228.v1

Gene Expression Comparison Between the Lymph Node-Positive and Negative Reveals a Peculiar Immune-microenvironment Signature and a Theranostic Role for WNT Targeting in Pancreatic Ductal Adenocarcinoma: A Pilot Study

Antonella Argentiero, Simona De Summa, Roberta Di Fonte, Rosa Maria Iacobazzi, Letizia Porcelli, matteo claudio da via, Oronzo Brunetti, Amalia Azzariti, Nicola Silvestris, ANTONIO GIOVANNI SOLIMANDO

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: pancreatic cancer; PDAC; lymph node metastases; WNT; dendritic cells; M2 macrophages; XAV-939; tumour immune-microenvironment

Online: 22 June 2019 (16:50:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0186.v1

Residence in Proximity of a Coal-Oil-Fired Thermal Power Plant and Risk of Lung and Bladder Cancer in North-Eastern Italy. A Population-Based Study, 1995–2009

Paolo Collarile, Ettore Bidoli, Fabio Barbone, Loris Zanier, Stefania Del Zotto, Simonetta Fuser, Fulvio Stel, Chiara Panato, Ilaria Gallai, Diego Serraino

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: air pollution; coal-fired thermal power plant; oil thermal power plant; geocoded; lung cancer; bladder cancer; north-eastern Italy

Online: 25 May 2017 (08:40:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints201709.0159.v1

Early Diagnosis of Breast Cancer – In Respect to Expectations of Participants in Screening Programs and to Contemporary Research in Imaging Methods

Heino Hille

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Key wordsbrest cancer screening, mammography, breast ultrasound, breast MRI

Online: 29 September 2017 (15:00:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202008.0528.v1

Canine Hemangiosarcoma: A Certainly Less Than Ideal, Very Ugly Cancer

Ashley Tinsley

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Hemangiosarcoma; neoplasia; oncology; metastasis; doxorubicin; hemoabdomen

Online: 24 August 2020 (10:08:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0082.v2

Characterization of Collagens Fibers (I, III, IV) and Elastin in the Extracellular Matrix of Normal and Neoplastic Canine Prostatic Tissues

Luis Gabriel Rivera Calderón, Priscila Emiko Kobayashi, Rosemeri Oliveira Vasconcelos, Carlos Eduardo Fonseca-Alves, Renee Laufer-Amorim

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: dog; prostatic tissue; extracellular matrix; picrosirius; immunohistochemistry

Online: 13 February 2019 (10:07:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints201801.0092.v1

Elevated Polyamines in Saliva of Pancreatic Cancer

Yasutsugu Asai, Takao Itoi, Masahiro Sugimoto, Atsushi Sofuni, Takayoshi Tsuchiya, Reina Tanaka, Ryosuke Tonozuka, Mitsuyoshi Honjo, Shuntaro Mukai, Mitsuru Fujita, Kenjiro Yamamoto, Yukitoshi Matsunami, Takashi Kurosawa, Yuichi Nagakawa, Miku Kaneko, Sana Ota, Shigeyuki Kawachi, Motohide Shimazu, Tomoyoshi Soga, Masaru Tomita, Makoto Sunamura

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: pancreatic cancer; saliva; metabolomics; polyamines

Online: 10 January 2018 (15:32:48 CET)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints201711.0122.v1

On Spatial Relations for Non-small Cells Lungs Cancer Interpretation

Nadeem Salamat, V. B. Surya Prasath, Malik M. Saad Missen

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: computer aided diagnosis; topological relations; TNM system; non-small Cells; lung cancer

Online: 20 November 2017 (07:57:32 CET)

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Medicine and Pharmacology