Version 1
: Received: 13 May 2024 / Approved: 14 May 2024 / Online: 14 May 2024 (13:10:13 CEST)
How to cite:
Tobal, R.; Potjewijd, J.; Doorn, D. P. C. V.; Empel, V. V.; Damoiseaux, J.; Paassen, P. V. High Prevalence of Myositis-Specific and Associated Antibodies in Patients with Pulmonary Hypertension. Preprints2024, 2024050959. https://doi.org/10.20944/preprints202405.0959.v1
Tobal, R.; Potjewijd, J.; Doorn, D. P. C. V.; Empel, V. V.; Damoiseaux, J.; Paassen, P. V. High Prevalence of Myositis-Specific and Associated Antibodies in Patients with Pulmonary Hypertension. Preprints 2024, 2024050959. https://doi.org/10.20944/preprints202405.0959.v1
Tobal, R.; Potjewijd, J.; Doorn, D. P. C. V.; Empel, V. V.; Damoiseaux, J.; Paassen, P. V. High Prevalence of Myositis-Specific and Associated Antibodies in Patients with Pulmonary Hypertension. Preprints2024, 2024050959. https://doi.org/10.20944/preprints202405.0959.v1
APA Style
Tobal, R., Potjewijd, J., Doorn, D. P. C. V., Empel, V. V., Damoiseaux, J., & Paassen, P. V. (2024). High Prevalence of Myositis-Specific and Associated Antibodies in Patients with Pulmonary Hypertension. Preprints. https://doi.org/10.20944/preprints202405.0959.v1
Chicago/Turabian Style
Tobal, R., J. Damoiseaux and P. van Paassen. 2024 "High Prevalence of Myositis-Specific and Associated Antibodies in Patients with Pulmonary Hypertension" Preprints. https://doi.org/10.20944/preprints202405.0959.v1
Abstract
Pulmonary hypertension (PH) is a serious condition linked to immune-system dysfunction. Myositis-specific/associated antibodies (MSA/MAA) play a role in idiopathic inflammatory myopathy (IIM) and interstitial lung disease (ILD), but their significance in PH remains unclear. We believe the presence of these antibodies, may be underestimated. This study analyzed adult PH patients without pre-existing IIM for MSA/MAA prevalence using a line-blot assay. We compared PH patients with and without ILD signs to a cohort clinically suspected of IIM/ILD (n=558). Our PH cohort (n=121) showed a significantly higher prevalence of overall weak positive MSA/MAAs and positive overlap syndrome-associated MAAs than the suspected IIM/ILD group (p
Keywords
Pulmonary Hypertension; Myositis specific antibodies; Myositis associated antibodies; Immunology; auto-antibodies
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
