Version 1
: Received: 11 May 2024 / Approved: 13 May 2024 / Online: 13 May 2024 (14:53:30 CEST)
How to cite:
Han, C.; Ning, X.; Burd, C. E.; Spakowicz, D. J.; Tounkara, F.; Kalady, M. F.; Noonan, A. M.; McCabe, S.; Von Ah, D. Chemotoxicity and Associated Risk Factors in Colorectal Cancer: A Systematic Review and Meta-Analysis. Preprints2024, 2024050890. https://doi.org/10.20944/preprints202405.0890.v1
Han, C.; Ning, X.; Burd, C. E.; Spakowicz, D. J.; Tounkara, F.; Kalady, M. F.; Noonan, A. M.; McCabe, S.; Von Ah, D. Chemotoxicity and Associated Risk Factors in Colorectal Cancer: A Systematic Review and Meta-Analysis. Preprints 2024, 2024050890. https://doi.org/10.20944/preprints202405.0890.v1
Han, C.; Ning, X.; Burd, C. E.; Spakowicz, D. J.; Tounkara, F.; Kalady, M. F.; Noonan, A. M.; McCabe, S.; Von Ah, D. Chemotoxicity and Associated Risk Factors in Colorectal Cancer: A Systematic Review and Meta-Analysis. Preprints2024, 2024050890. https://doi.org/10.20944/preprints202405.0890.v1
APA Style
Han, C., Ning, X., Burd, C. E., Spakowicz, D. J., Tounkara, F., Kalady, M. F., Noonan, A. M., McCabe, S., & Von Ah, D. (2024). Chemotoxicity and Associated Risk Factors in Colorectal Cancer: A Systematic Review and Meta-Analysis. Preprints. https://doi.org/10.20944/preprints202405.0890.v1
Chicago/Turabian Style
Han, C., Susan McCabe and Diane Von Ah. 2024 "Chemotoxicity and Associated Risk Factors in Colorectal Cancer: A Systematic Review and Meta-Analysis" Preprints. https://doi.org/10.20944/preprints202405.0890.v1
Abstract
Background: Colorectal cancer (CRC) patients experienced multiple chemotoxicity affecting treatment compliance, survival, and quality of life (QOL). Prior research shows clinician-reported chemotoxicity (i.e., grading scales or diagnostic codes) predicts rehospitalization and cancer survival. However, a comprehensive synthesis of clinician-reported chemotoxicity is still lacking. Objectives: We conducted a systematic review and meta-analysis to determine the chemotoxicity's prevalence and risk factors in CRC. Methods: A systematic search from 2009 to 2024 yielded 30 studies for review, with 25 included in the meta-analysis. Results: Pooled prevalences of overall, non-hematological, and hematological moderate-to-severe toxicities were 45.7%, 39.2%, and 25.3%, respectively. The most common clinician-reported chemotoxicities were gastrointestinal (GI) toxicity (22.9%) and neuropathy or neutropenia (17.9%). Significant risk factors at baseline were malnutritional status, frailty, impaired immune or hepato-renal functions, short telomere lengths, low gut lactobacillus levels, age, female sex, aggressive chemotherapy, and low QOL. Age was associated with neutropenia (β: -1.44) and GI toxicity (β:1.85) (Ps 65 y.o.) had higher prevalences of overall (OR: 1.14) and GI (OR: 1.65) toxicities, but a lower prevalence of neutropenia (OR: 0.65) than younger adults (Ps
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
,
,
,
