Version 1
: Received: 13 May 2024 / Approved: 13 May 2024 / Online: 13 May 2024 (10:45:06 CEST)
How to cite:
Malamos, P.; Papanikolaou, C.; Gavriatopoulou, M.; Dimopoulos, M. A.; Terpos, E.; Souliotis, V. L. The Interplay between the DNA Damage Response (DDR) Network and the Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Multiple Myeloma. Preprints2024, 2024050832. https://doi.org/10.20944/preprints202405.0832.v1
Malamos, P.; Papanikolaou, C.; Gavriatopoulou, M.; Dimopoulos, M. A.; Terpos, E.; Souliotis, V. L. The Interplay between the DNA Damage Response (DDR) Network and the Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Multiple Myeloma. Preprints 2024, 2024050832. https://doi.org/10.20944/preprints202405.0832.v1
Malamos, P.; Papanikolaou, C.; Gavriatopoulou, M.; Dimopoulos, M. A.; Terpos, E.; Souliotis, V. L. The Interplay between the DNA Damage Response (DDR) Network and the Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Multiple Myeloma. Preprints2024, 2024050832. https://doi.org/10.20944/preprints202405.0832.v1
APA Style
Malamos, P., Papanikolaou, C., Gavriatopoulou, M., Dimopoulos, M. A., Terpos, E., & Souliotis, V. L. (2024). The Interplay between the DNA Damage Response (DDR) Network and the Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Multiple Myeloma. Preprints. https://doi.org/10.20944/preprints202405.0832.v1
Chicago/Turabian Style
Malamos, P., Evangelos Terpos and Vassilis L. Souliotis. 2024 "The Interplay between the DNA Damage Response (DDR) Network and the Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Multiple Myeloma" Preprints. https://doi.org/10.20944/preprints202405.0832.v1
Abstract
The DNA Damage Response (DDR) network and the mitogen-activated protein kinase (MAPK) signaling pathway are crucial mechanisms for the survival of all living beings. An accumulating body of evidence suggests that there is a crosstalk between these two systems, thus favoring the appropriate functioning of multi-cellular organisms. On the other hand, aberrations within these mechanisms are thought to play a vital role in the onset and progression of several diseases, including cancer, as well as in the emergence of drug resistance. Here, we provide an overview of the current knowledge regarding alterations in the DDR machinery and the MAPK signaling pathway, as well as abnormalities in the DDR-MAPK functional crosstalk in multiple myeloma, the second most common hematologic malignancy. We also present the latest advances in the development of anti-myeloma drugs targeting crucial DDR- and MAPK-associated molecular components. These data could potentially be exploited to discover new therapeutic targets and effective biomarkers, as well as for the design of novel clinical trials. Interestingly, they might provide a new approach to increase the efficacy of anti-myeloma therapy by combining drugs targeting the DDR network and the MAPK signaling pathway.
Keywords
multiple myeloma (MM); DNA damage response (DDR); mitogen‑activated protein kinase (MAPK); DDR-MAPK interplay; combination therapy
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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