Brief Report
Version 1
Preserved in Portico This version is not peer-reviewed
Gene Interactions in Cerebral Cavernous Malformations: A Brief Report
Version 1
: Received: 12 May 2024 / Approved: 13 May 2024 / Online: 13 May 2024 (12:30:13 CEST)
How to cite: Avecilla, V. Gene Interactions in Cerebral Cavernous Malformations: A Brief Report. Preprints 2024, 2024050746. https://doi.org/10.20944/preprints202405.0746.v1 Avecilla, V. Gene Interactions in Cerebral Cavernous Malformations: A Brief Report. Preprints 2024, 2024050746. https://doi.org/10.20944/preprints202405.0746.v1
Abstract
Cerebral cavernous malformation (CCM) is a collection of irregular small blood vessels that may be present in the brain or spinal cord. These vessels contain slow – moving blood that commonly clot. These malformations are frequently caused by mutations in one of the CCM genes. The CCM1 (also known as KRIT1) gene is essential for vascular morphogenesis however, its interactions with transcriptional regulators are unknown. Inhibitor of DNA-Binding/Differentiation-3 (ID3) has been recognized to be involved in different vascular/blood vessel diseases such as peripheral arterial disease, stroke, arteriovenous malformations, and atherosclerosis. We show interactions between ID3 and additional key differential expressed genes (DEGs) in microarray data of overexpressed CCM1 in endothelial cells through bioinformatic and data analytic tools. Improved understanding of how ID3, CCM1, and DEGs interact will play an important role in adding to the increasing knowledge for creating therapeutic targets for cerebral cavernous malformations.
Keywords
cerebral cavernous malformations; CCM1; differential expressed genes; gene networks; ID3
Subject
Biology and Life Sciences, Life Sciences
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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