Review
Version 1
Preserved in Portico This version is not peer-reviewed
Aged-Related Changes in Microglia and Neurodegenerative Diseases: Exploring the Connection
Version 1
: Received: 24 April 2024 / Approved: 10 May 2024 / Online: 13 May 2024 (11:43:38 CEST)
How to cite: Ana, B. Aged-Related Changes in Microglia and Neurodegenerative Diseases: Exploring the Connection. Preprints 2024, 2024050722. https://doi.org/10.20944/preprints202405.0722.v1 Ana, B. Aged-Related Changes in Microglia and Neurodegenerative Diseases: Exploring the Connection. Preprints 2024, 2024050722. https://doi.org/10.20944/preprints202405.0722.v1
Abstract
Microglial cells are brain macrophages that support and protect the central nervous system enviroment. Aging induces alterations in microglial polarization, resulting in a shift towards a neurotoxic phenotype characterized by increased expression of pro-inflammatory markers. Dysregulation of microglial cells regulatory pathways and interactions with neurons contribute to chronic activation and neurodegeneration. A better understanding the involvement of microglia in neurodegenerative diseases like Alzheimer's and Parkinson's, is a critical topic to studying the role of inflammatory responses in disease progression. Furthermore, the metabolic changes in aged microglia, including downregulation of oxidative phosphorylation are discussed in this review. Understanding these mechanisms is crucial for developing better preventive and therapeutic strategies.
Keywords
Microglia; Neurodegenetrative diseases; Aging; inflammation; Oxidative stress
Subject
Biology and Life Sciences, Life Sciences
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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