Effect of Modulator Therapies on Nutritional Risk Index in Adults with Cystic Fibrosis: A Prospective Cohort Study

Nadir Yalcin; Esen Deniz Akman; Oğuz Karcıoğlu; Karel Allegaert; Kutay Demirkan; Ebru Damadoglu; Ali Fuat Kalyoncu

doi:10.20944/preprints202404.1989.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 29 April 2024 / Approved: 30 April 2024 / Online: 30 April 2024 (14:33:36 CEST)

Background: Modulator therapies improve weight and body mass index (BMI) in cystic fibrosis (CF) patients. We aimed to compare the nutritional risk index (NRI) in adult CF patients receiving modulator (MT) or only non-modulator (conventional) therapies (non-MT). Methods: A single-center prospective cohort study was conducted between June-December 2023. The NRI based on weight gain and albumin was calculated at beginning and end of a 12 weeks period in both groups. This design was pragmatic, since based on individual patient access to MT for 12 weeks. Results: 107 patients were included [mean (SD) age: 23.85 (4.98) years, 54.7% male, 46.7% MT]. In the MT group, mean (SD) weight (kg) and albumin (g/dL) increased significantly [changes: +3.09 (2.74) and +0.17 (0.37); p

cystic fibrosis; adults; nutritional risk index; nutritional therapy; modulators; rare disease; orphan disease

Medicine and Pharmacology, Pharmacy

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Effect of Modulator Therapies on Nutritional Risk Index in Adults with Cystic Fibrosis: A Prospective Cohort Study

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