Gu, Y.; Zhang, Q.; Zhao, Y.; Niu, Q. Ameliorative Effects of Curcumin on Type 2 Diabetes Mellitus. Preprints2024, 2024041926. https://doi.org/10.20944/preprints202404.1926.v1
APA Style
Gu, Y., Zhang, Q., Zhao, Y., & Niu, Q. (2024). Ameliorative Effects of Curcumin on Type 2 Diabetes Mellitus. Preprints. https://doi.org/10.20944/preprints202404.1926.v1
Chicago/Turabian Style
Gu, Y., Yanfang Zhao and Qun Niu. 2024 "Ameliorative Effects of Curcumin on Type 2 Diabetes Mellitus" Preprints. https://doi.org/10.20944/preprints202404.1926.v1
Abstract
Type 2 diabetes mellitus (T2DM), a multifactorial and complicated metabolic disorder, is a growing public health problems. Numerous studies indicated that bioactive compounds from herbal medicine have beneficial effects on T2DM prevention and treatment, owing to their numerous biological properties. Curcumin, the major curcuminoid of turmeric, is one of the most studied bioactive components of herbal supplements, which has a variety of biological activities. Clinical trials and preclinical research have recently produced compelling data to demonstrate the crucial functions of curcumin against T2DM via several routes. Accordingly, this review systematically summarizes the antidiabetic activity of curcumin, along with various mechanisms. Results showed that effectiveness of curcumin on T2DM is due to it being anti-inflammatory, anti-oxidant, anti-hyperglycemic, anti-apoptotic, anti-hyperlipidemia and other activities. In light of these results, curcumin may be a promising prevention/treatment choice for T2DM.
Keywords
Curcumin; Type 2 diabetes mellitus; Antidiabetic activity; Molecular mechanisms
Subject
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
