Markers of Occult Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma (HNSCC): A Systematic Review

Piero Giuseppe Meliante; Sofia Pizzolante; Luca Perna; Chiara Filippi; Giorgio Bandiera; Christian Barbato; Antonio Minni; Marco de Vincentiis; Edoardo Covelli

doi:10.20944/preprints202404.1712.v1

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preprints.org > medicine and pharmacology > oncology and oncogenics > doi: 10.20944/preprints202404.1712.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Markers of Occult Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma (HNSCC): A Systematic Review

Piero Giuseppe Meliante

Version 1 : Received: 25 April 2024 / Approved: 26 April 2024 / Online: 26 April 2024 (08:14:18 CEST)

How to cite: Meliante, P.G.; Pizzolante, S.; Perna, L.; Filippi, C.; Bandiera, G.; Barbato, C.; Minni, A.; de Vincentiis, M.; Covelli, E. Markers of Occult Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma (HNSCC): A Systematic Review. Preprints 2024, 2024041712. https://doi.org/10.20944/preprints202404.1712.v1 Meliante, P.G.; Pizzolante, S.; Perna, L.; Filippi, C.; Bandiera, G.; Barbato, C.; Minni, A.; de Vincentiis, M.; Covelli, E. Markers of Occult Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma (HNSCC): A Systematic Review. Preprints 2024, 2024041712. https://doi.org/10.20944/preprints202404.1712.v1

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MDPI and ACS Style

Meliante, P.G.; Pizzolante, S.; Perna, L.; Filippi, C.; Bandiera, G.; Barbato, C.; Minni, A.; de Vincentiis, M.; Covelli, E. Markers of Occult Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma (HNSCC): A Systematic Review. Preprints 2024, 2024041712. https://doi.org/10.20944/preprints202404.1712.v1

APA Style

Meliante, P.G., Pizzolante, S., Perna, L., Filippi, C., Bandiera, G., Barbato, C., Minni, A., de Vincentiis, M., & Covelli, E. (2024). Markers of Occult Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma (HNSCC): A Systematic Review. Preprints. https://doi.org/10.20944/preprints202404.1712.v1

Chicago/Turabian Style

Meliante, P.G., Marco de Vincentiis and Edoardo Covelli. 2024 "Markers of Occult Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma (HNSCC): A Systematic Review" Preprints. https://doi.org/10.20944/preprints202404.1712.v1

Abstract

Background: The accurate diagnosis of regional lymph node metastasis is critical for guiding treatment decisions in head and neck cancer patients. Despite advances in imaging techniques, detecting nodal metastasis remains challenging, leading to potential undertreatment or overtreatment. This systematic review aims to identify molecular markers associated with occult metastasis in Head and Neck Squamous Cell Carcinoma (HNSCC) patients. Methods: The present research was conducted following PRISMA guidelines. Prospero registration nr. CRD42024522985. Results: Through a comprehensive literature search and review process, 634 articles were considered, 103 of them were finally included. Conclusions: Several promising markers were identified, including miR-205, DSG3, pan-CK AE1/AE3, HPV-16, Activin-A, Cyclin D1, and NPL that demonstrated effectiveness across multiple studies. Future research should focus on exploring combination scoring systems to improve diagnostic precision and optimize treatment selection in HNSCC patients.

Keywords

Head and neck squamous cell carcinoma; Meastasis; Lymp Node; Regional Metastasis; Cancer Marker; Occult Metastasis

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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