Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Advancements in Immunology and Microbiology Research: A Comprehensive Exploration of Key Areas and Global Impact

Version 1 : Received: 24 April 2024 / Approved: 25 April 2024 / Online: 25 April 2024 (16:44:18 CEST)

How to cite: Justiz-Vaillant, A.A.; Gopaul, D.; Soodeen, S.; Arozarena-Fundora, R.; Unakal, C.; Asin-Milan, O.; Akpaka, P.E. Advancements in Immunology and Microbiology Research: A Comprehensive Exploration of Key Areas and Global Impact. Preprints 2024, 2024041686. https://doi.org/10.20944/preprints202404.1686.v1 Justiz-Vaillant, A.A.; Gopaul, D.; Soodeen, S.; Arozarena-Fundora, R.; Unakal, C.; Asin-Milan, O.; Akpaka, P.E. Advancements in Immunology and Microbiology Research: A Comprehensive Exploration of Key Areas and Global Impact. Preprints 2024, 2024041686. https://doi.org/10.20944/preprints202404.1686.v1

Abstract

Immunology and microbiology research in the West Indies has witnessed remarkable growth and innovation, playing a pivotal role in advancing our understanding of immune mechanisms, disease pathogenesis, and therapeutic interventions. This manuscript presents a comprehensive exploration of key areas in West Indian immunology research, spanning from the utilization of bacterial proteins as antibody reagents to the intricate realms of clinical immunology and disease management. The utilization of bacterial immunoglobulin-binding proteins (IBPs), including protein A (SpA), protein G (SpG), and protein L (SpL), has revolutionised serological diagnostics in the region. promise in early disease detection and precision medicine. Microbiological studies in the Caribbean region have shed light on antimicrobial resistance patterns, particularly the emergence of extended-spectrum beta-lactamases (ESBLs), guiding antimicrobial stewardship programs and informing therapeutic strategies. Clinical immunology research has elucidated the molecular pathways underlying immune-mediated disorders, leading to tailored management strategies for conditions such as severe combined immunodeficiency (SCID), neuropsychiatric lupus erythematosus (NPLE), and others. In summary, West Indian immunology and microbiology research has made significant contributions to global healthcare, fostering collaboration, innovation, and improved patient outcomes.

Keywords

Bacterial proteins; Extended-spectrum beta-lactamases (ESBLs); West Indies; NPLE; Experimental vaccines; Tuberculosis; Global healthcare

Subject

Biology and Life Sciences, Immunology and Microbiology

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