Version 1
: Received: 25 April 2024 / Approved: 25 April 2024 / Online: 25 April 2024 (12:03:06 CEST)
How to cite:
Desai, D.; Al-azzawi, H.; Shah, H.; Shah, A.; Barot, R.; Raval, D. Diagnostic Performance Of Ultrasonography In Biliary Atresia- A Test Accuracy Meta-analysis. Preprints2024, 2024041676. https://doi.org/10.20944/preprints202404.1676.v1
Desai, D.; Al-azzawi, H.; Shah, H.; Shah, A.; Barot, R.; Raval, D. Diagnostic Performance Of Ultrasonography In Biliary Atresia- A Test Accuracy Meta-analysis. Preprints 2024, 2024041676. https://doi.org/10.20944/preprints202404.1676.v1
Desai, D.; Al-azzawi, H.; Shah, H.; Shah, A.; Barot, R.; Raval, D. Diagnostic Performance Of Ultrasonography In Biliary Atresia- A Test Accuracy Meta-analysis. Preprints2024, 2024041676. https://doi.org/10.20944/preprints202404.1676.v1
APA Style
Desai, D., Al-azzawi, H., Shah, H., Shah, A., Barot, R., & Raval, D. (2024). Diagnostic Performance Of Ultrasonography In Biliary Atresia- A Test Accuracy Meta-analysis. Preprints. https://doi.org/10.20944/preprints202404.1676.v1
Chicago/Turabian Style
Desai, D., Raj Barot and Dwija Raval. 2024 "Diagnostic Performance Of Ultrasonography In Biliary Atresia- A Test Accuracy Meta-analysis" Preprints. https://doi.org/10.20944/preprints202404.1676.v1
Abstract
Introduction: Biliary Atresia (BA) is a common cause of neonatal cholestatic jaundice which, if recognized and treated early, can be life-saving for the infant. If the liver biopsy suggests the presence of BA, exploratory laparotomy is then carried out to confirm the diagnosis, along with the Kasai procedure to provide drainage to the bile secreted by the liver. The purpose of this study is to get a deep dive into all the various imaging modalities that can diagnose BA more effectively and with absolute certitude, thus helping prevent several children from a grave prognosis.Methodology: For the collection of the data, a search was done by two individuals using PubMed, Google Scholar, and Cochrane Library databases for all relevant literature. Each qualifying paper was evaluated independently by two reviewers. Each article was analyzed for the number of patients, their age, procedure modality, complexity of ethology, and incidence of the pre-decided complications. The statistical software packages RevMan (Review Manager, version 5.3), SPSS (Statistical Package for the Social Sciences, version 20), Google Sheets, and Excel in Stata 14 were used to perform the statistical analyses. The data was obtained and entered into analytic software.Results: A total of 39 studies with 3,679 subjects were selected for the study, out of which 7 studies showed sensitivity above or equal to 95%, and an astounding 14 studies showed specificity above 95%. The value of True Positive (TP) was 1280, that of True Negative (TN) was 1817, that of False Positive (FP) was 239, and that of False Negative (FN) was 343. With a confidence interval of 95%, sensitivity, specificity, and positive predictive values were calculated. The sensitivity of Ultrasonography for Biliary Atresia is 0.79, with a CI of 95% in a range of 0.77 to 0.81. The specificity of Ultrasonography for Biliary Atresia is 0.88, with a CI of 95% in a range of 0.87 to 0.90. Conclusion: Even though several radiological techniques at present help to detect BA, USG of the abdomen proves to be an effective diagnostic and a modest screening test for the detection of BA.
Keywords
biliary atresia, USG, diagnosis, meta-analysis, Index test, Reference standard
Subject
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
