Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Clinical Outcome of Patients with Escherichia coli Isolated from Catheter Lumens and/or Peripheral Blood Cultures: A Retrospective Analysis

Álvaro Irigoyen-von-Sierakowsi
ORCID logo ,
Marta Díaz-Navarro
ORCID logo ,
Andrés Visedo
,
María Jesús Pérez-Granda
,
Pablo Martín-Rabadán
,
Patricia Munoz
ORCID logo ,
María Guembe
*
Version 1 : Received: 23 April 2024 / Approved: 23 April 2024 / Online: 23 April 2024 (16:57:14 CEST)

How to cite: Irigoyen-von-Sierakowsi, Á.; Díaz-Navarro, M.; Visedo, A.; Pérez-Granda, M.J.; Martín-Rabadán, P.; Munoz, P.; Guembe, M. Clinical Outcome of Patients with Escherichia coli Isolated from Catheter Lumens and/or Peripheral Blood Cultures: A Retrospective Analysis. Preprints 2024, 2024041549. https://doi.org/10.20944/preprints202404.1549.v1 Irigoyen-von-Sierakowsi, Á.; Díaz-Navarro, M.; Visedo, A.; Pérez-Granda, M.J.; Martín-Rabadán, P.; Munoz, P.; Guembe, M. Clinical Outcome of Patients with Escherichia coli Isolated from Catheter Lumens and/or Peripheral Blood Cultures: A Retrospective Analysis. Preprints 2024, 2024041549. https://doi.org/10.20944/preprints202404.1549.v1

Abstract

Background. Escherichia coli commonly causes catheter-related bloodstream infection (C-RBSI) in specific populations. The differential time to positivity (DTTP) technique is the recommended conservative procedure for diagnosing C-RBSIs. Methods. We conducted a retrospective study of episodes in which E. coli was isolated from catheter lumens obtained using the DTTP technique. We analysed microbiological and clinical data based on the DTTP technique as either catheter colonization, C-RBSI, or non-C-RBSI. Results. We included 89 catheter blood cultures classified as follows: catheter colonization, 33.7%; C-RSBI, 9.0%; and non-C-RBSI, 57,3%. Catheter withdrawal was 15.7% without positive catheter-tip cultures. We found no statistically significant differences in catheter type, antibiotic treatment, or clinical outcome among groups, except for the frequency of catheter lock therapy or in the frequency of successful treatment. Mortality was associated with C-RBSI in only 1 patient. Conclusion. E. coli bacteremia diagnosed by the DTTP technique was non-catheter related in most patients. As the majority of the catheters were retained, E. coli bacteremia could not be microbiologically confirmed or ruled out as catheter related by catheter-tip culture. Future studies are needed to assess the profitability of the DTTP technique for diagnosing E. coli C-RBSIs..

Keywords

Escherichia coli; bacteremia; catheter; lock therapy; differential time to positivity; biofilm; outcome.

Subject

Medicine and Pharmacology, Epidemiology and Infectious Diseases

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.