TAFRO Syndrome on 18F-FDG-PET/CT: An Appealing Diagnostic Tool

Ayoub Jaafari; Nadim Taheri; Sohaïb Mansour; Saïf-Eddine El Bouhali; Rachid Attou

doi:10.20944/preprints202404.1483.v1

Preprint Interesting Images Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 22 April 2024 / Approved: 23 April 2024 / Online: 23 April 2024 (11:58:18 CEST)

TAFRO syndrome (TS) is a rare variant of idiopathic multicentric Castleman's disease (iMCD) characterized by a confluence of symptoms: thrombocytopenia (T), anasarca (A), fever (F), reticulin myelofibrosis (R), and organomegaly (O). First described in Japan in 2010, the pathogenesis of the disease remains unclear. Due to its heterogeneous presentation and potential life-threatening delays in diagnosis, precise diagnosis is essential. According to the literature, no specific imaging modality has been recommended for the work-up of patients with suspected TS. Here, we report a case of TS and its management using 18F-FDG-PET/CT imaging as an attractive complementary diagnostic tool.

TAFRO syndrome; multicentric Castleman disease; iMCD; 18F-FDG-PET/CT

Medicine and Pharmacology, Internal Medicine

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TAFRO Syndrome on 18F-FDG-PET/CT: An Appealing Diagnostic Tool

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