Protective Effects of Pyridoxine Hydrochloride on the Incidence of Corticosteroid-Induced Cleft Palate in C57BL/6J Mice Offsprings

Sherif Hassan; Wael Abdelhameed; Ibraheem Bamaga; Abdullah Holdar; Alaa Al-Qutub; Reda Nofal; Mahmoud Sherif

doi:10.20944/preprints202404.1444.v1

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preprints.org > medicine and pharmacology > dentistry and oral surgery > doi: 10.20944/preprints202404.1444.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Protective Effects of Pyridoxine Hydrochloride on the Incidence of Corticosteroid-Induced Cleft Palate in C57BL/6J Mice Offsprings

^* ,

Version 1 : Received: 22 April 2024 / Approved: 22 April 2024 / Online: 23 April 2024 (12:55:19 CEST)

How to cite: Hassan, S.; Abdelhameed, W.; Bamaga, I.; Holdar, A.; Al-Qutub, A.; Nofal, R.; Sherif, M. Protective Effects of Pyridoxine Hydrochloride on the Incidence of Corticosteroid-Induced Cleft Palate in C57BL/6J Mice Offsprings. Preprints 2024, 2024041444. https://doi.org/10.20944/preprints202404.1444.v1 Hassan, S.; Abdelhameed, W.; Bamaga, I.; Holdar, A.; Al-Qutub, A.; Nofal, R.; Sherif, M. Protective Effects of Pyridoxine Hydrochloride on the Incidence of Corticosteroid-Induced Cleft Palate in C57BL/6J Mice Offsprings. Preprints 2024, 2024041444. https://doi.org/10.20944/preprints202404.1444.v1

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MDPI and ACS Style

Hassan, S.; Abdelhameed, W.; Bamaga, I.; Holdar, A.; Al-Qutub, A.; Nofal, R.; Sherif, M. Protective Effects of Pyridoxine Hydrochloride on the Incidence of Corticosteroid-Induced Cleft Palate in C57BL/6J Mice Offsprings. Preprints 2024, 2024041444. https://doi.org/10.20944/preprints202404.1444.v1

APA Style

Hassan, S., Abdelhameed, W., Bamaga, I., Holdar, A., Al-Qutub, A., Nofal, R., & Sherif, M. (2024). Protective Effects of Pyridoxine Hydrochloride on the Incidence of Corticosteroid-Induced Cleft Palate in C57BL/6J Mice Offsprings. Preprints. https://doi.org/10.20944/preprints202404.1444.v1

Chicago/Turabian Style

Hassan, S., Reda Nofal and Mahmoud Sherif. 2024 "Protective Effects of Pyridoxine Hydrochloride on the Incidence of Corticosteroid-Induced Cleft Palate in C57BL/6J Mice Offsprings" Preprints. https://doi.org/10.20944/preprints202404.1444.v1

Abstract

Abstract: Cleft palate is a congenital condition result from incomplete fusion of palatine shelves. The current study aimed to assess the effects of vitamin B6 on the incidence of corticosteroid-induced cleft palate model. Eighteen pregnant mice were divided into three groups. Mice of control group were injected with sterile physiological saline from 11th - 14th days of gestation. Mice of group II were injected with 125 mg/kg hydrocortisone from 11th - 14th days of gestation. Mice of group III were injected with hydrocortisone as in group II and given drinking water containing 500 µg/ml of vitamin B6 from day zero of gestation until delivery. Two days after delivery, the offspring were counted, and their head circumferences were taken for statistical analysis. The heads of the offspring were fixed and processed for paraffin sectioning and stained with hematoxylin and eosin. Cleft palates were counted and statistically analyzed using ANOVA test to determine any significances (P

Keywords

palatine shelves; cleft palate; vitamin B6; hydrocortisone

Subject

Medicine and Pharmacology, Dentistry and Oral Surgery

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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