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Comparing the Outcomes of Matched and Mismatched Unrelated Allogeneic Hematopoietic Stem Cell Transplantation with Different Anti-thymocyte Globulin Formulations. A Retrospective, Double-Centre Experience on Behalf of the Polish Adult Leukaemia Group
Version 1
: Received: 17 April 2024 / Approved: 18 April 2024 / Online: 18 April 2024 (09:15:41 CEST)
How to cite:
Giordano, U.; Mordak-Domagała, M.; Sobczyk-Kruszelnicka, M.; Giebel, S.; Gil, L.; Dudek, K.; Dybko, J. Comparing the Outcomes of Matched and Mismatched Unrelated Allogeneic Hematopoietic Stem Cell Transplantation with Different Anti-thymocyte Globulin Formulations. A Retrospective, Double-Centre Experience on Behalf of the Polish Adult Leukaemia Group. Preprints2024, 2024041232. https://doi.org/10.20944/preprints202404.1232.v1
Giordano, U.; Mordak-Domagała, M.; Sobczyk-Kruszelnicka, M.; Giebel, S.; Gil, L.; Dudek, K.; Dybko, J. Comparing the Outcomes of Matched and Mismatched Unrelated Allogeneic Hematopoietic Stem Cell Transplantation with Different Anti-thymocyte Globulin Formulations. A Retrospective, Double-Centre Experience on Behalf of the Polish Adult Leukaemia Group. Preprints 2024, 2024041232. https://doi.org/10.20944/preprints202404.1232.v1
Giordano, U.; Mordak-Domagała, M.; Sobczyk-Kruszelnicka, M.; Giebel, S.; Gil, L.; Dudek, K.; Dybko, J. Comparing the Outcomes of Matched and Mismatched Unrelated Allogeneic Hematopoietic Stem Cell Transplantation with Different Anti-thymocyte Globulin Formulations. A Retrospective, Double-Centre Experience on Behalf of the Polish Adult Leukaemia Group. Preprints2024, 2024041232. https://doi.org/10.20944/preprints202404.1232.v1
APA Style
Giordano, U., Mordak-Domagała, M., Sobczyk-Kruszelnicka, M., Giebel, S., Gil, L., Dudek, K., & Dybko, J. (2024). Comparing the Outcomes of Matched and Mismatched Unrelated Allogeneic Hematopoietic Stem Cell Transplantation with Different Anti-thymocyte Globulin Formulations. A Retrospective, Double-Centre Experience on Behalf of the Polish Adult Leukaemia Group. Preprints. https://doi.org/10.20944/preprints202404.1232.v1
Chicago/Turabian Style
Giordano, U., Krzysztof Dudek and Jarosław Dybko. 2024 "Comparing the Outcomes of Matched and Mismatched Unrelated Allogeneic Hematopoietic Stem Cell Transplantation with Different Anti-thymocyte Globulin Formulations. A Retrospective, Double-Centre Experience on Behalf of the Polish Adult Leukaemia Group" Preprints. https://doi.org/10.20944/preprints202404.1232.v1
Abstract
Despite notable advancements in immunotherapy in the past decades, allogeneic hematopoietic stem cell transplantation (allo-HCT) remains a promising, potentially curative treatment modality. Only a limited number of studies has performed a direct comparison of two prevalent rabbit anti-thymocyte globulin (r-ATG) formulations — specifically, Thymoglobuline (ATG-T, formerly Genzyme) and Grafalon (ATG-G, formerly Fresenius). The primary objective of our retrospective analysis was to compare the outcomes of adult patients undergoing matched or mismatched unrelated donor (MUD/MMUD) allo-HCT, with a graft-versus-host disease (GvHD) prophylaxis based on either ATG-T or ATG-G. A total of 87 patients undergone allo-HCT between 2012 and 2022 were included. We observed no significant differences between ATG-T and ATG-G concerning the occurrence of acute graft-versus-host disease (aGvHD), regardless of its severity. Conversely, chronic graft-versus-host disease (cGvHD) occurred less frequently in the ATG-T group compared to ATG-G (7.5% vs. 38.3%, p=0.001). Patients treated with ATG-T manifested a higher incidence of cytomegalovirus (CMV) reactivations (70% vs. 31.9%, p<0.001), with a shorter time between transplant and CMV (<61 days, 77.8% vs. 33.3%, p=0.008) and a higher median CMV copy number (1000 vs. 0, p=0.004). Notably, despite a higher occurrence of CMV reactivations in the ATG-T cohort, most patients were asymptomatic compared to ATG-G (85.7% vs. 43.8%, p=0.005). Finally, we observed no significant differences in terms of 5-year overall survival (OS) and 3-year probability of relapse while comparing ATG-T and ATG-G (32.0% vs 40.3%, p=0.423; 63.9% vs 55.7%, p=0.438, respectively).
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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