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Coronary Computed Tomography Angiography - derived modified Duke index is associated with peri-coronary Fat Attenuation Index and predicts severity of coronary inflammation
Halațiu, V.; Benedek, I.; Rodean, I.; Cojocariu, L.; Mihăilă, T.; Blîndu, E.; Roșca, A.; Mátyás, B.-.B.; Gerculy, R.; Buicu, F.; Benedek, T. Coronary Computed Tomography Angiography - derived modified Duke index is associated with peri-coronary Fat Attenuation Index and predicts severity of coronary inflammation. Preprints2024, 2024041207. https://doi.org/10.20944/preprints202404.1207.v1
APA Style
Halațiu, V., Benedek, I., Rodean, I., Cojocariu, L., Mihăilă, T., Blîndu, E., Roșca, A., Mátyás, B.-.B., Gerculy, R., Buicu, F., & Benedek, T. (2024). Coronary Computed Tomography Angiography - derived modified Duke index is associated with peri-coronary Fat Attenuation Index and predicts severity of coronary inflammation. Preprints. https://doi.org/10.20944/preprints202404.1207.v1
Chicago/Turabian Style
Halațiu, V., Florin Buicu and Theodora Benedek. 2024 "Coronary Computed Tomography Angiography - derived modified Duke index is associated with peri-coronary Fat Attenuation Index and predicts severity of coronary inflammation" Preprints. https://doi.org/10.20944/preprints202404.1207.v1
Abstract
Background: The modified Duke index derived from coronary computed tomography angiography (CCTA) was designed to predict cardiovascular outcomes based on the severity of coronary ste-nosis. However, it does not take into consideration the presence or severity of peri-coronary in-flammation. The peri-coronary fat attenuation index (FAI) is a novel imaging marker determined by CCTA which reflects the degree of inflammation in the coronary tree in patients with coronary artery disease. Purpose: To assess the association between the modified Duke index assessed by CCTA, cardiovascular risk factors and peri-coronary inflammation in the coronary arteries of pa-tients with coronary artery disease. Methods: One hundred seventy-two patients who underwent CCTA for typical angina were assigned into two groups based on the modified Duke index: group 1 – patients with low index ≤ 3 (n=107) and group 2 – patients with high index > 3 (n=65). Demo-graphic, clinical and CCTA data were collected for all patients, and FAI analysis of coronary in-flammation was performed. Results: Patients with increased values of the modified Duke index were significantly older compared to those with a low index (61.83 ± 9.89 vs. 64.78 ± 8.9; p = 0.002). No differences were found between the two groups in terms of gender distribution, hypertension, hypercholesterolemia or smoking history (all p > 0.5). The FAI score was significantly higher in patients from group 2, who presented a significantly higher score of inflammation compared to the patients in group 1, especially at the level of the right coronary artery (FAI score 20.85 ± 15.80 vs. 14.61 ± 16.66; p = 0.01 for the right coronary artery, 13.85 ± 8.04 vs. 10.91 ± 6.5; p = 0.01 for the circumflex artery, and 13.26 ±10.18 vs. 11.37 ± 8.84; p = 0.2 for the left anterior descending artery). CaRi-Heart® analysis identified a significantly higher risk of future events among patients with a high modified Duke index (34.84 % ± 25.86 % versus 16.87 % ± 15.80 %; p
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
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