Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Blood plasma lipidomic profile in atherosclerosis of brachiocephalic arteries

Anastasiia Lomonosova
* ORCID logo ,
Daria Gognieva
,
Aleksandr Suvorov
ORCID logo ,
Artemy Silantiev
,
Alina Abasheva
ORCID logo ,
Yana Vasina
,
Magomed Abdullaev
ORCID logo ,
Anna Nartova
,
Nikolay Eroshchenko
,
Roman Komarov
,
Andrey Dzyundzya
,
Dmitry Shchekochikhin
ORCID logo ,
Philipp Kopylov
Version 1 : Received: 15 April 2024 / Approved: 17 April 2024 / Online: 17 April 2024 (14:36:46 CEST)

How to cite: Lomonosova, A.; Gognieva, D.; Suvorov, A.; Silantiev, A.; Abasheva, A.; Vasina, Y.; Abdullaev, M.; Nartova, A.; Eroshchenko, N.; Komarov, R.; Dzyundzya, A.; Shchekochikhin, D.; Kopylov, P. Blood plasma lipidomic profile in atherosclerosis of brachiocephalic arteries. Preprints 2024, 2024041174. https://doi.org/10.20944/preprints202404.1174.v1 Lomonosova, A.; Gognieva, D.; Suvorov, A.; Silantiev, A.; Abasheva, A.; Vasina, Y.; Abdullaev, M.; Nartova, A.; Eroshchenko, N.; Komarov, R.; Dzyundzya, A.; Shchekochikhin, D.; Kopylov, P. Blood plasma lipidomic profile in atherosclerosis of brachiocephalic arteries. Preprints 2024, 2024041174. https://doi.org/10.20944/preprints202404.1174.v1

Abstract

According to the World Health Organisation ischemic stroke is the second leading cause of death in the world. More frequent it is caused by brachiocephalic arteries (BCA) atherosclerosis. Timely detection of the atherosclerosis and it`s unstable course can allow a timely response to potentially dangerous changes and reduce the risk of vascular complications. Omics technologies allow us to identify new biomarkers that we can use in diagnosing diseases. The research included 90 blood plasma samples. The first group - 52 patients with severe atherosclerotic lesions, second group - 38 patients with no BCA atherosclerosis. Targeted and panoramic lipidomic profiling of blood plasma was carried out. There is a statistically significant difference (р

Keywords

atherosclerosis; lipidome; stroke; brachiocephalic arteries; atherosclerotic plaque; triacylglycerides; lipidomics; mass-spectrometry

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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