Significance of Cellular Lipid Metabolism for the Replication of Rotaviruses and Other RNA Viruses

Ulrich Desselberger

doi:10.20944/preprints202404.1097.v1

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preprints.org > biology and life sciences > virology > doi: 10.20944/preprints202404.1097.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Significance of Cellular Lipid Metabolism for the Replication of Rotaviruses and Other RNA Viruses

Ulrich Desselberger

Version 1 : Received: 15 April 2024 / Approved: 16 April 2024 / Online: 17 April 2024 (15:03:18 CEST)

How to cite: Desselberger, U. Significance of Cellular Lipid Metabolism for the Replication of Rotaviruses and Other RNA Viruses. Preprints 2024, 2024041097. https://doi.org/10.20944/preprints202404.1097.v1 Desselberger, U. Significance of Cellular Lipid Metabolism for the Replication of Rotaviruses and Other RNA Viruses. Preprints 2024, 2024041097. https://doi.org/10.20944/preprints202404.1097.v1

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MDPI and ACS Style

Desselberger, U. Significance of Cellular Lipid Metabolism for the Replication of Rotaviruses and Other RNA Viruses. Preprints 2024, 2024041097. https://doi.org/10.20944/preprints202404.1097.v1

APA Style

Desselberger, U. (2024). Significance of Cellular Lipid Metabolism for the Replication of Rotaviruses and Other RNA Viruses. Preprints. https://doi.org/10.20944/preprints202404.1097.v1

Chicago/Turabian Style

Desselberger, U. 2024 "Significance of Cellular Lipid Metabolism for the Replication of Rotaviruses and Other RNA Viruses" Preprints. https://doi.org/10.20944/preprints202404.1097.v1

Abstract

The replication of species A rotaviruses (RVAs) and other RNA viruses involves recruitment of and inter-action with the cellular organelles lipid droplets (LDs), both physically and functionally. Inhibition of en-zymes involved in the cellular fatty acid biosynthesis pathway or of cellular lipases that degrade LDs re-duces the functions of ‘viral factories’ (viroplasms for rotaviruses or replication compartments of other RNA viruses) and decreases the production of infectious progeny virus. Similarly, disturbance of the cellular lipid homeostasis in various ways blocks the replication of flaviviruses (hepatitis C viruses, Zikavirus, others), HIV-1, SARS-CoV-2, picornaviruses, noroviruses, influenza viruses and other negative-strand RNA viruses.

Keywords

Lipid metabolism; RNA virus replication; Rotavirus; hepatitis C virus; flaviviruses; picornaviruses; no-roviruses; HIV-1; SARS-CoV-2; influenza viruses

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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