Version 1
: Received: 16 April 2024 / Approved: 16 April 2024 / Online: 17 April 2024 (11:38:22 CEST)
How to cite:
Dave, K.; Sharma, M.; Patel, D.; Dhanda, P.S.; Yadav, A.; Jain, M. Genomic Approaches for Drug Repurposing. Preprints2024, 2024041075. https://doi.org/10.20944/preprints202404.1075.v1
Dave, K.; Sharma, M.; Patel, D.; Dhanda, P.S.; Yadav, A.; Jain, M. Genomic Approaches for Drug Repurposing. Preprints 2024, 2024041075. https://doi.org/10.20944/preprints202404.1075.v1
Dave, K.; Sharma, M.; Patel, D.; Dhanda, P.S.; Yadav, A.; Jain, M. Genomic Approaches for Drug Repurposing. Preprints2024, 2024041075. https://doi.org/10.20944/preprints202404.1075.v1
APA Style
Dave, K., Sharma, M., Patel, D., Dhanda, P.S., Yadav, A., & Jain, M. (2024). Genomic Approaches for Drug Repurposing. Preprints. https://doi.org/10.20944/preprints202404.1075.v1
Chicago/Turabian Style
Dave, K., Alpa Yadav and Mukul Jain. 2024 "Genomic Approaches for Drug Repurposing" Preprints. https://doi.org/10.20944/preprints202404.1075.v1
Abstract
Functional genomics, a multidisciplinary subject, investigates the functions of genes and their products in biological systems to better understand diseases and find new drugs. Drug repurposing is an economically efficient approach that entails discovering novel therapeutic applications for already-available medications. Genomics enables the identification of illness and therapeutic molecular characteristics and interactions, which in turn facilitates the process of drug repurposing. Techniques like gene expression profiling and Mendelian randomization are helpful in identifying possible medication candidates. Progress in computer science allows for the investigation and modelling of gene expression networks that involve large amounts of data. The integration of data from DNA, RNA, and protein activities has resemblance to pharmacogenomics, which is of utmost importance in the development of cancer drugs. Functional genomics in drug discovery, particularly for cancer, is still not thoroughly investigated, despite the existence of a significant amount of literature on the subject. Next-generation sequencing and proteomics present highly intriguing opportunities. Publicly available databases and mining techniques facilitate the development of cancer treatments based on functional genomics. Expanding the study and application of functional genomics has great promise to advance the process of discovering and repurposing drugs, especially in the field of oncology.
Keywords
drug repurposing; genomics; Proteomics; NGS
Subject
Biology and Life Sciences, Life Sciences
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
,
*
,
