Giordano, G.; Guareschi, D.; Thai, E. Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A Rare Polyphenotypic Neoplasm. Preprints2024, 2024041037. https://doi.org/10.20944/preprints202404.1037.v1
APA Style
Giordano, G., Guareschi, D., & Thai, E. (2024). Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A Rare Polyphenotypic Neoplasm. Preprints. https://doi.org/10.20944/preprints202404.1037.v1
Chicago/Turabian Style
Giordano, G., Debora Guareschi and Elena Thai. 2024 "Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A Rare Polyphenotypic Neoplasm" Preprints. https://doi.org/10.20944/preprints202404.1037.v1
Abstract
Uterine Tumor Resembling Ovarian Sex Cord Stromal Tumor (UTROSCT) is a rare uterine mesenchymal neoplasm, which resembles ovarian sex cord tumors of the ovary. Although, in general, UTROSCT exhibits benign behavior with a favorable prognosis, this neoplasm is nonetheless classified as being of an uncertain ma-lignant potential, given its low rate of recurrence and the fact that it rarely pro-duces metastases (lymph nodes, epiploic appendix, omentum, small bowel, subcutaneous, lungs). Its histogenesis too is uncertain. Typically, UTROSCT oc-curs in peri-menopausal or menopausal women but can sometimes be observed in young women. Usually, this neoplasm can be found in the uterine corpus as a nodular intramural lesion, less frequently submucosal, subserosal or poly-poid/intracavitary. UTROSCT can cause abnormal bleeding, pelvic pain, enlarged uterus, mass sensation, but sometimes it is found purely by chance. This neo-plasm can be considered polyphenotypic on morphological, immunohistochem-ical, and genetic analyses. Generally, on microscopic examination, UTROSCT shows a predominant pattern of the cords, nests, and trabeculae typical of sex cord tumors of the ovary while, immunohistochemically, it is characterized by a co-expression of epithelial, smooth muscle, and sex cord markers. The aim of this review is to report clinical and pathological data and genetic alterations to estab-lish its impact on the prognosis and management of patients affected by this rare entity.
Medicine and Pharmacology, Pathology and Pathobiology
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