Version 1
: Received: 14 April 2024 / Approved: 15 April 2024 / Online: 15 April 2024 (14:22:05 CEST)
How to cite:
Bermejo Valdés, A.J.; Archer Jiménez, J. A Novel Presentation: Epsilon Waves in the Electrocardiogram of a Patient with Dravet Syndrome Without Structural Heart Disease. Preprints2024, 2024040976. https://doi.org/10.20944/preprints202404.0976.v1
Bermejo Valdés, A.J.; Archer Jiménez, J. A Novel Presentation: Epsilon Waves in the Electrocardiogram of a Patient with Dravet Syndrome Without Structural Heart Disease. Preprints 2024, 2024040976. https://doi.org/10.20944/preprints202404.0976.v1
Bermejo Valdés, A.J.; Archer Jiménez, J. A Novel Presentation: Epsilon Waves in the Electrocardiogram of a Patient with Dravet Syndrome Without Structural Heart Disease. Preprints2024, 2024040976. https://doi.org/10.20944/preprints202404.0976.v1
APA Style
Bermejo Valdés, A.J., & Archer Jiménez, J. (2024). A Novel Presentation: Epsilon Waves in the Electrocardiogram of a Patient with Dravet Syndrome Without Structural Heart Disease. Preprints. https://doi.org/10.20944/preprints202404.0976.v1
Chicago/Turabian Style
Bermejo Valdés, A.J. and Jessica Archer Jiménez. 2024 "A Novel Presentation: Epsilon Waves in the Electrocardiogram of a Patient with Dravet Syndrome Without Structural Heart Disease" Preprints. https://doi.org/10.20944/preprints202404.0976.v1
Abstract
We document for the first time epsilon waves on the electrocardiogram of a patient with Dravet syndrome (DS) who does not exhibit structural cardiac pathology. DS, a severe form of pediatric epilepsy, involves mutations in the SCN1A gene, which disrupt sodium ion flow and increase the risk of sudden unexpected death in epilepsy. The epsilon waves, typically associated with arrhythmogenic right ventricular dysplasia, may also suggest a link between neuronal and cardiac dysfunctions. In our case, the epsilon waves appear to originate from abnormalities in sodium channels rather than structural changes in the myocardium. This finding underscores the importance of assessing both neurological and cardiac manifestations in patients with severe epilepsy, opening new avenues for the research and treatment of these interactions in DS.
Keywords
Dravet syndrome; epsilon waves; arrhythmogenic right ventricular dysplasia; sudden unexpected death in epilepsy; SCN1A gene
Subject
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
