Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Zingiber Officinale and Azadirachta Indica Partially Ameliorates Paracetamol Induced Liver Damage: Rodent Modeling Study

Shafaq Sana
,
Muhammad Tauseef Sultan
* ORCID logo ,
Ahmad Mujtaba Noman
,
Muhammad Israr
,
Rizwan Azhar
,
Codrut Ciurea
* ,
Marius Irimie
* ,
Radu Necula
*
Version 1 : Received: 15 April 2024 / Approved: 15 April 2024 / Online: 15 April 2024 (09:51:31 CEST)

How to cite: Sana, S.; Sultan, M.T.; Noman, A.M.; Israr, M.; Azhar, R.; Ciurea, C.; Irimie, M.; Necula, R. Zingiber Officinale and Azadirachta Indica Partially Ameliorates Paracetamol Induced Liver Damage: Rodent Modeling Study. Preprints 2024, 2024040938. https://doi.org/10.20944/preprints202404.0938.v1 Sana, S.; Sultan, M.T.; Noman, A.M.; Israr, M.; Azhar, R.; Ciurea, C.; Irimie, M.; Necula, R. Zingiber Officinale and Azadirachta Indica Partially Ameliorates Paracetamol Induced Liver Damage: Rodent Modeling Study. Preprints 2024, 2024040938. https://doi.org/10.20944/preprints202404.0938.v1

Abstract

The liver diseases are posing serious threat to human health associated with abusive use of allopathy medicines, especially in developing economies like Pakistan. The strengthening of detoxification system using natural products might be a suitable option to minimize the liver problems. In this current research, Zingiber officinale and Azadirachta indica were evaluated for their hepatoprotective role. For the purpose, 20 Sprague Dawley rats were equally divided into four groups i.e., negative control, paracetamol positive control, 2.5% ginger and 2% neem powder, respectively. During 42 days study, the levels of bilirubin and liver enzymes significantly elevated due to liver damage. Although, the values dropped (20-25%) in treatment group. Serum glucose and serum lipid profile increased in positive control group, but reduced (5-10%) in both ginger and neem groups. The serum protein profile declined in liver damage group, however, improved (~5%) in treatment groups. The hematological parameters slightly declined in liver damage group, but increased in ginger and neem groups. Moreover, the white blood cells differential count and renal parameters showed abnormal values in liver damage group, but improved after treatment. This study is promising and highlighted the hepato-protective role of neem and ginger that may open several avenues of research.

Keywords

acetaminophen; liver damage; ginger; neem; Medicinal Plants; liver function test

Subject

Medicine and Pharmacology, Dietetics and Nutrition

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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