Ruiz Belmonte, L.M.; Carrera-Lasfuentes, P.; Cebollada-Solanas, A.; Scarpignato, C.; Lanas, A.; Gargallo-Puyuelo, C.J. Predictive Score for Advanced Colorectal Neoplasia Based on Cardiovascular and Colorectal Cancer Risk Factors. Preprints2024, 2024040892. https://doi.org/10.20944/preprints202404.0892.v1
APA Style
Ruiz Belmonte, L.M., Carrera-Lasfuentes, P., Cebollada-Solanas, A., Scarpignato, C., Lanas, A., & Gargallo-Puyuelo, C.J. (2024). Predictive Score for Advanced Colorectal Neoplasia Based on Cardiovascular and Colorectal Cancer Risk Factors. Preprints. https://doi.org/10.20944/preprints202404.0892.v1
Chicago/Turabian Style
Ruiz Belmonte, L.M., Angel Lanas and Carla J. Gargallo-Puyuelo. 2024 "Predictive Score for Advanced Colorectal Neoplasia Based on Cardiovascular and Colorectal Cancer Risk Factors" Preprints. https://doi.org/10.20944/preprints202404.0892.v1
Abstract
BACKGROUND AND AIMS: Cardiovascular disease and colorectal cancer (CRC) are significant health problems and share some risk factors. The aim of our study was to develop and validate a predictive score for advanced colorectal neoplasia (CRN) based on risk factors for cardiovascular disease and CRC. MATERIALS AND METHODS: A cross-sectional study comprising a derivation cohort and an external validation cohort of 1049 and 308 patients respectively. A prediction score for advanced CRN (CRNAS: Colorectal Neoplasia Advanced Score) was developed from a logistic regression model, comprising sex, age, first-degree family history for CRC, systolic and diastolic blood pressure, total cholesterol, HDL-cholesterol, body mass index, diabetes, smoking, and antihypertensive treatment. Other cardiovascular risk scores (Framingham-Wilson, REGICOR, SCORE and FRESCO) were also used to predict the risk of advanced CRN. The discriminatory capacity of each score was evaluated using the area under the curve (AUC). RESULTS: CRN were found in 379 subjects from the derivation cohort (36%) including 228 patients (22%) with an advanced CRN. Male sex, age, diabetes, and smoking were identified as independent risk factors for advanced CRN. The newly created score (CRNAS), showed an AUC of 0.68 (95% CI: 0.64-0.73) for advanced CRN, which was better than cardiovascular risk scores (p
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
,
,
