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Urinary L-FABP as an Early Biomarker for Pediatric Acute Kidney Injury Following Cardiac Surgery with Cardiopulmonary Bypass: A Systematic Review and Meta-analysis
Wilnes, B.; Castello-Branco, B.; Branco, B.C.; Sanglard, A.; Vaz de Castro, P.A.S.; Simões-e-Silva, A.C. Urinary L-FABP as an Early Biomarker for Pediatric Acute Kidney Injury Following Cardiac Surgery with Cardiopulmonary Bypass: A Systematic Review and Meta-Analysis. Int. J. Mol. Sci.2024, 25, 4912.
Wilnes, B.; Castello-Branco, B.; Branco, B.C.; Sanglard, A.; Vaz de Castro, P.A.S.; Simões-e-Silva, A.C. Urinary L-FABP as an Early Biomarker for Pediatric Acute Kidney Injury Following Cardiac Surgery with Cardiopulmonary Bypass: A Systematic Review and Meta-Analysis. Int. J. Mol. Sci. 2024, 25, 4912.
Wilnes, B.; Castello-Branco, B.; Branco, B.C.; Sanglard, A.; Vaz de Castro, P.A.S.; Simões-e-Silva, A.C. Urinary L-FABP as an Early Biomarker for Pediatric Acute Kidney Injury Following Cardiac Surgery with Cardiopulmonary Bypass: A Systematic Review and Meta-Analysis. Int. J. Mol. Sci.2024, 25, 4912.
Wilnes, B.; Castello-Branco, B.; Branco, B.C.; Sanglard, A.; Vaz de Castro, P.A.S.; Simões-e-Silva, A.C. Urinary L-FABP as an Early Biomarker for Pediatric Acute Kidney Injury Following Cardiac Surgery with Cardiopulmonary Bypass: A Systematic Review and Meta-Analysis. Int. J. Mol. Sci. 2024, 25, 4912.
Abstract
Acute kidney injury (AKI) following surgery with cardiopulmonary bypass (CPB-AKI) is common in pediatrics. Urinary liver-type fatty acid binding protein (uL-FABP) increases in some kidney diseases and may indicate CPB-AKI earlier than current methods. The aim of this systematic review with meta-analysis was to evaluate the potential role of uL-FABP in early predicting CPB-AKI. Databases Pubmed/MEDLINE, Scopus, and Web of Science were searched on November 12th, 2023, using the MeSH terms “Children”, “CPB”, “L-FABP”, and “Acute Kidney Injury”. Included papers were revised. AUC values from similar studies were pooled by meta-analysis, performed using random- and fixed-effect models, with p
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
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