Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Bactericidal Chitosan Derivatives and Their Superabsorbent Blends with ĸ – Carrageenan

Kamila Lewicka
,
Anna Smola-Dmochowska
ORCID logo ,
Natalia Smigiel -Gac
ORCID logo ,
Bożena Kaczmarczyk
,
Henryk Janeczek
,
Renata Barczyńska-Felusiak
ORCID logo ,
Izabela Szymanek
,
Piotr Rychter
,
Piotr Dobrzyński
* ORCID logo
Version 1 : Received: 25 March 2024 / Approved: 26 March 2024 / Online: 26 March 2024 (11:30:13 CET)

A peer-reviewed article of this Preprint also exists.

Lewicka, K.; Smola-Dmochowska, A.; Śmigiel-Gac, N.; Kaczmarczyk, B.; Janeczek, H.; Barczyńska-Felusiak, R.; Szymanek, I.; Rychter, P.; Dobrzyński, P. Bactericidal Chitosan Derivatives and Their Superabsorbent Blends with ĸ-Carrageenan. Int. J. Mol. Sci. 2024, 25, 4534. Lewicka, K.; Smola-Dmochowska, A.; Śmigiel-Gac, N.; Kaczmarczyk, B.; Janeczek, H.; Barczyńska-Felusiak, R.; Szymanek, I.; Rychter, P.; Dobrzyński, P. Bactericidal Chitosan Derivatives and Their Superabsorbent Blends with ĸ-Carrageenan. Int. J. Mol. Sci. 2024, 25, 4534.

Abstract

The aim of this work is research dedicated to the search for new bactericidal systems for use in cosmetic formulations, dermocosmetics, or the production of wound dressings. Over the last two decades chitosan due to its special biological activity, has become a highly indispensable biopolymer with very wide application possibilities. Literature reports on the antibacterial effects of chitosan are very diverse, but our research has shown that they can be successfully improved through chemical modification. Therefore, in this study, results on the synthesis of new Schiff bases chitosan – dCsSB-SFD and dCsSB-PCA obtained using two aldehydes: sodium 4-formylbenzene-1,3-disulfonate (SFD) and 2-pyridine carboxaldehyde (PCA) respectively. Chitosan derivatives synthesized in this way demonstrate stronger antimicrobial activity. Carrying out the procedure of grafting chitosan with a caproyl chain allowed obtaining compatible blends of chitosan derivatives with κ-carrageenan, which are stable hydrogels with a high swelling coefficient. Furthermore, covalently bounded PCL improved the solubility of obtained polymers in organic solvents. With this respect, the Schiff base-containing polymers obtained in this study, with special hydrogel and antimicrobial properties are very promising materials for the potential use as a controlled-release formulation of both, hydrophilic and hydrophobic drugs in cosmetic products for skin health.

Keywords

biodegradable polymers; antibacterial polymers; chitosan Schiff base; κ-carrageenan blend; grafted copolymer

Subject

Chemistry and Materials Science, Polymers and Plastics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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