Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

Analysis of Cell Immunity for Children Infected with COVID-19 and Those Vaccinated against COVID-19 Using T-SPOT®.COVID

Tomohiro Oishi
* ORCID logo ,
Yuto Yasui
,
Atsushi Kato
,
Satoko Ogita
,
Takahiro Eitoku
,
Hideo Enoki
,
Takashi Nakano
Version 1 : Received: 18 March 2024 / Approved: 18 March 2024 / Online: 19 March 2024 (02:25:56 CET)

How to cite: Oishi, T.; Yasui, Y.; Kato, A.; Ogita, S.; Eitoku, T.; Enoki, H.; Nakano, T. Analysis of Cell Immunity for Children Infected with COVID-19 and Those Vaccinated against COVID-19 Using T-SPOT®.COVID. Preprints 2024, 2024031033. https://doi.org/10.20944/preprints202403.1033.v1 Oishi, T.; Yasui, Y.; Kato, A.; Ogita, S.; Eitoku, T.; Enoki, H.; Nakano, T. Analysis of Cell Immunity for Children Infected with COVID-19 and Those Vaccinated against COVID-19 Using T-SPOT®.COVID. Preprints 2024, 2024031033. https://doi.org/10.20944/preprints202403.1033.v1

Abstract

To elucidate the cellular immune response to coronavirus disease (COVID-19) among children, we assessed cellular immunity in 8 children post-vaccination for COVID-19 and 11 children after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, using the T-SPOT®.COVID assay for both the spike (S) and nucleocapsid (N) proteins. In the vaccinated group, the T-SPOT®.COVID assay for the S protein yielded positive results in all eight children. In contrast, in the post-infection group, the assay for the N protein was positive in 5 of 11 children, with 3 of these 5 children requiring hospital admission, including 2 who needed mechanical ventilation. Therefore, the T-SPOT®.COVID assay is valuable for assessing cellular immunity against COVID-19, and most children infected with COVID-19 may not develop such immunity unless the disease severity is significant.

Keywords

cell immunity; COVID-19; children; T-Spot®

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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