Coxsackievirus A7 and Enterovirus A71 Significally Reduce SARS-CoV-2 Infection in Cell and Animal Models

Victor A. Svyatchenko; Stanislav S. Legostaev; Roman Y Lutkovskiy; Elena V. Protopopova; Eugenia P. Ponomareva; Vladimir V. Omigov; Oleg S. Taranov; Vladimir A. Ternovoi; Alexander P. Agafonov; Valery B. Loktev

doi:10.20944/preprints202403.0822.v1

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preprints.org > biology and life sciences > virology > doi: 10.20944/preprints202403.0822.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Coxsackievirus A7 and Enterovirus A71 Significally Reduce SARS-CoV-2 Infection in Cell and Animal Models

Victor A. Svyatchenko

Stanislav S. Legostaev

Roman Y Lutkovskiy

Elena V. Protopopova

Eugenia P. Ponomareva

Vladimir V. Omigov

Oleg S. Taranov

Vladimir A. Ternovoi

Alexander P. Agafonov

Valery B. Loktev

Version 1 : Received: 13 March 2024 / Approved: 14 March 2024 / Online: 14 March 2024 (09:33:51 CET)

How to cite: Svyatchenko, V. A.; Legostaev, S. S.; Lutkovskiy, R. Y.; Protopopova, E. V.; Ponomareva, E. P.; Omigov, V. V.; Taranov, O. S.; Ternovoi, V. A.; Agafonov, A. P.; Loktev, V. B. Coxsackievirus A7 and Enterovirus A71 Significally Reduce SARS-CoV-2 Infection in Cell and Animal Models. Preprints 2024, 2024030822. https://doi.org/10.20944/preprints202403.0822.v1 Svyatchenko, V. A.; Legostaev, S. S.; Lutkovskiy, R. Y.; Protopopova, E. V.; Ponomareva, E. P.; Omigov, V. V.; Taranov, O. S.; Ternovoi, V. A.; Agafonov, A. P.; Loktev, V. B. Coxsackievirus A7 and Enterovirus A71 Significally Reduce SARS-CoV-2 Infection in Cell and Animal Models. Preprints 2024, 2024030822. https://doi.org/10.20944/preprints202403.0822.v1

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MDPI and ACS Style

Svyatchenko, V. A.; Legostaev, S. S.; Lutkovskiy, R. Y.; Protopopova, E. V.; Ponomareva, E. P.; Omigov, V. V.; Taranov, O. S.; Ternovoi, V. A.; Agafonov, A. P.; Loktev, V. B. Coxsackievirus A7 and Enterovirus A71 Significally Reduce SARS-CoV-2 Infection in Cell and Animal Models. Preprints 2024, 2024030822. https://doi.org/10.20944/preprints202403.0822.v1

APA Style

Svyatchenko, V. A., Legostaev, S. S., Lutkovskiy, R. Y., Protopopova, E. V., Ponomareva, E. P., Omigov, V. V., Taranov, O. S., Ternovoi, V. A., Agafonov, A. P., & Loktev, V. B. (2024). Coxsackievirus A7 and Enterovirus A71 Significally Reduce SARS-CoV-2 Infection in Cell and Animal Models. Preprints. https://doi.org/10.20944/preprints202403.0822.v1

Chicago/Turabian Style

Svyatchenko, V. A., Alexander P. Agafonov and Valery B. Loktev. 2024 "Coxsackievirus A7 and Enterovirus A71 Significally Reduce SARS-CoV-2 Infection in Cell and Animal Models" Preprints. https://doi.org/10.20944/preprints202403.0822.v1

Abstract

In this study, we investigated the features of co-infection with SARS-CoV-2 and nonpathogenic strain LEV8 of coxsackievirus A7 or enterovirus A71 for Vero E6 cells and Syrian hamsters. The investigation of co-infection with SARS-СoV-2 and LEV-8 or EV-A71 in the cell model was shown that a competitive inhibitory effect for these viruses were especially significant against SARS-CoV-2. Pre-infection with enteroviruses in animals caused more than a 100-fold decrease in the levels of SARS-CoV-2 virus replication in the respiratory tracts and more rapid clearance of the lower respiratory tract from infectious SARS-CoV-2. Co-infection with SARS-CoV-2 and LEV-8 or EV-A71 also reduced the severity of clinical manifestations of the SARS-CoV-2 infection for animals. Additionally, the histological data illustrated that co-infection with nonpathogenic coxsackievirus decreased the level of pathological changes by SARS-CoV-2 in the lungs. Research into the chemokine/cytokine profile demonstrated that the studied enteroviruses efficiently triggered this part of antiviral immune response, which can be associated with significant inhibition of SARS-CoV-2 infection. These results demonstrate that there exists a strong viral interference between the studied nonpathogenic strain of coxsackievirus A7 or enteroviruses A71 and SARS-CoV-2 pathogenic for humans in vitro and in vivo.

Keywords

SARS-CoV-2; coxsackievirus A7; enterovirus A71; co-infection; Syrian hamster

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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