Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Preventing Bone Loss in Breast Cancer Patients: Designing a Personalized Clinical Pathway in a Large-Volume Research Hospital

Inbal Dona Amar
* ORCID logo ,
Gianluca Franceschini
* ,
Camilla Nero
ORCID logo ,
Ilaria Pasqua
,
Ida Paris
ORCID logo ,
Armando Orlandi
ORCID logo ,
Stefania Gori
ORCID logo ,
Alessandra Fabi
,
Giorgia Garganese
,
Giovanni Scambia
,
Paola Villa
Version 1 : Received: 11 March 2024 / Approved: 12 March 2024 / Online: 12 March 2024 (08:01:05 CET)

A peer-reviewed article of this Preprint also exists.

Amar, I.D.; Franceschini, G.; Nero, C.; Pasqua, I.; Paris, I.; Orlandi, A.; Gori, S.; Fabi, A.; Garganese, G.; Scambia, G.; Villa, P. Preventing Bone Loss in Breast Cancer Patients: Designing a Personalized Clinical Pathway in a Large-Volume Research Hospital. J. Pers. Med. 2024, 14, 371. Amar, I.D.; Franceschini, G.; Nero, C.; Pasqua, I.; Paris, I.; Orlandi, A.; Gori, S.; Fabi, A.; Garganese, G.; Scambia, G.; Villa, P. Preventing Bone Loss in Breast Cancer Patients: Designing a Personalized Clinical Pathway in a Large-Volume Research Hospital. J. Pers. Med. 2024, 14, 371.

Abstract

Background: Assessing the impact of bone health clinical management in breast cancer (BC) patients receiving adjuvant endocrine therapy and designing a personalized clinical pathway to reduce bone loss, in an Italian research hospital. Methods: The primary endpoint was to assess (through the process improvement organizational method) the clinical pathway that post-surgical BC patients prescribed with endocrine therapy undergo to prevent bone loss. The secondary endpoint was to design a personalized clinical pathway for a prompt implementation of guidelines, to assess and possibly prescribe antiresorptive therapy. Results: During the first year of the new diagnostic therapeutic assistance pathway execution, an 60% increase in Dual-Energy X-ray Absorptiometry evaluations within 30 days and a 39.5% increase in antiresorptive therapy prescription within 90 days (since prescription of endocrine therapy) were shown, thus increasing patients’ compliance. Conclusion: Case managers and bone health specialists in this context can improve patients’ adherence to therapies and bone health, helping physicians to expand their collaboration.

Keywords

Breast Cancer; Clinical Pathways; Menopause; Osteoporosis; Patient Care Management

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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