Review
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NHC-Catalyzed Cross-Coupling of Aldehydes for C(sp2)−O Bond Formation
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Version 1
: Received: 7 March 2024 / Approved: 7 March 2024 / Online: 7 March 2024 (11:09:09 CET)
A peer-reviewed article of this Preprint also exists.
Yamaoka, Y.; Miyabe, H. NHC-Catalyzed Reaction of Aldehydes for C(sp2)–O Bond Formation. Catalysts 2024, 14, 219. Yamaoka, Y.; Miyabe, H. NHC-Catalyzed Reaction of Aldehydes for C(sp2)–O Bond Formation. Catalysts 2024, 14, 219.
Abstract
In the past few decades, N-heterocyclic carbenes (NHCs) open the new field of organocatalysis in synthetic organic chemistry. This review highlights the dramatic progress in the NHC-catalyzed C−O bond formation based on the activation of aldehyde C(sp2)−H bonds. The oxidative and redox transformations for the synthesis of various molecules with structural diversity and complexity are summarized. Furthermore, new methods and strategies for NHC catalysis are emerging continuously; thus, cooperative catalysis with Brønsted acid, hydrogen-bonding catalyst, transition-metal catalyst, and photocatalyst is also described.
Keywords
N-heterocyclic carbenes; organocatalysis; C−O bond formation; aldehyde; cooperative catalysis
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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