Martin-Moro, F.; Lopez-Jimenez, J.; Garcia-Marco, J.A.; Garcia-Vela, J.A. Comparative Review of the Current and Future Strategies to Evaluate Bone Marrow Infiltration at Diffuse Large B-Cell Lymphoma Diagnosis. Diagnostics2024, 14, 658.
Martin-Moro, F.; Lopez-Jimenez, J.; Garcia-Marco, J.A.; Garcia-Vela, J.A. Comparative Review of the Current and Future Strategies to Evaluate Bone Marrow Infiltration at Diffuse Large B-Cell Lymphoma Diagnosis. Diagnostics 2024, 14, 658.
Martin-Moro, F.; Lopez-Jimenez, J.; Garcia-Marco, J.A.; Garcia-Vela, J.A. Comparative Review of the Current and Future Strategies to Evaluate Bone Marrow Infiltration at Diffuse Large B-Cell Lymphoma Diagnosis. Diagnostics2024, 14, 658.
Martin-Moro, F.; Lopez-Jimenez, J.; Garcia-Marco, J.A.; Garcia-Vela, J.A. Comparative Review of the Current and Future Strategies to Evaluate Bone Marrow Infiltration at Diffuse Large B-Cell Lymphoma Diagnosis. Diagnostics 2024, 14, 658.
Abstract
Diffuse large B-cell lymphoma (DLBCL) requires a complete staging at diagnosis that may have prognostic and therapeutic implications. The role of bone marrow (BM) biopsy (BMB) is contro-versial in the era of nuclear-imaging techniques. We performed a comparative review of 25 studies focused on BM evaluation at DLBCL diagnosis, including at least two of the following techniques: BMB, flow cytometry, and positron emission tomography (PET-FDG). The report about BM involvement (BMi), diagnostic accuracy and prognostic significance was collected and compared among techniques. A concordance analysis between BMB, FCM and PET was also per-formed, and we deeply evaluated the implications of the different types of BMi: concordant by LBCL or discordant by low-grade B-cell lymphoma for both BMB and FCM, and focal or diffuse uptake pattern for PET. As main conclusion, BMB, FCM and PET are complementary tools which provide different and clinically relevant information in the assessment of BMi in newly DLBCL.
Keywords
Bone marrow; Large B cell lymphoma; Lymphoma; Histology; Flow cytometry; PET
Subject
Medicine and Pharmacology, Hematology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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