Version 1
: Received: 7 March 2024 / Approved: 7 March 2024 / Online: 7 March 2024 (11:15:23 CET)
How to cite:
Odah, M.A.A. The Vital Role of Non-coding RNA Regions in Hemoglobin Gene Regulation. Preprints2024, 2024030421. https://doi.org/10.20944/preprints202403.0421.v1
Odah, M.A.A. The Vital Role of Non-coding RNA Regions in Hemoglobin Gene Regulation. Preprints 2024, 2024030421. https://doi.org/10.20944/preprints202403.0421.v1
Odah, M.A.A. The Vital Role of Non-coding RNA Regions in Hemoglobin Gene Regulation. Preprints2024, 2024030421. https://doi.org/10.20944/preprints202403.0421.v1
APA Style
Odah, M.A.A. (2024). The Vital Role of Non-coding RNA Regions in Hemoglobin Gene Regulation. Preprints. https://doi.org/10.20944/preprints202403.0421.v1
Chicago/Turabian Style
Odah, M.A.A. 2024 "The Vital Role of Non-coding RNA Regions in Hemoglobin Gene Regulation" Preprints. https://doi.org/10.20944/preprints202403.0421.v1
Abstract
Non-coding RNA regions have long been considered the "dark matter" of the genome, with their significance in gene regulation remaining enigmatic. However, recent advances in genomics and molecular biology have illuminated the pivotal role that non-coding RNA regions play in the fine-tuned orchestration of hemoglobin expression. Hemoglobin, the oxygen-carrying protein vital for life, is tightly regulated, and any disruption in its production can lead to severe medical conditions, such as hemoglobinopathies. This review delves into the intricate world of non-coding RNA regions, exploring how they act as master conductors in controlling hemoglobin gene expression. We will discuss various classes of non-coding RNAs, including long non-coding RNAs, microRNAs, and circular RNAs, and their specific mechanisms in fine-tuning hemoglobin levels. Additionally, we will highlight emerging therapeutic approaches that target non-coding RNA regions to ameliorate hemoglobin-related disorders. Understanding the critical role of non-coding RNA regions in hemoglobin regulation opens new avenues for precision medicine and gene therapies, offering hope for those affected by hemoglobinopathies and related conditions. This comprehensive review sheds light on the significance of these non-coding RNA regions, demonstrating that the "silent" players in the genome are, in fact, the conductors of harmony in the symphony of hemoglobin regulation.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
