Ilia, I.; Ciordas, P.D.; Nitusca, D.; Anton, A.; Marian, C. Analysis of the Level of Adiponectin and Selected Cytokines in Patients with Knee Osteoarthritis. Medicina2024, 60, 571.
Ilia, I.; Ciordas, P.D.; Nitusca, D.; Anton, A.; Marian, C. Analysis of the Level of Adiponectin and Selected Cytokines in Patients with Knee Osteoarthritis. Medicina 2024, 60, 571.
Ilia, I.; Ciordas, P.D.; Nitusca, D.; Anton, A.; Marian, C. Analysis of the Level of Adiponectin and Selected Cytokines in Patients with Knee Osteoarthritis. Medicina2024, 60, 571.
Ilia, I.; Ciordas, P.D.; Nitusca, D.; Anton, A.; Marian, C. Analysis of the Level of Adiponectin and Selected Cytokines in Patients with Knee Osteoarthritis. Medicina 2024, 60, 571.
Abstract
Background and Objectives: Knee osteoarthritis (KOA) is a degenerative disease that is targeting continuously people of different ages, but especially the elderly population, the number of which tends to increase continuously at the global level. Apart from age, excess weight can influence the evolution of the disease, with obesity being associated with a weak inflammation stage, and an imbalance between pro-inflammatory and anti-inflammatory cytokines. The present work aimed to identify specific biomarkers alike ACRP-30, IL-10, TNF-α, and IL-6 in synovial fluid and correlate them with patients’ clinical data. Materials and Methods: 24 subjects with KOA and over 50 years of age are involved in the present study. All patients performed a supine X-ray at the target knee. Ultrasound was performed using an ESAOTE MyLab Omega (ESAOTE Spa, Italy) ultrasound device and a 6-19 MHz linear array transducer. Results: The obtained results highlighted a significant correlation between age and adiponectin level (p=0.0451, r=-0.412). Also, the IL-10 values are lower in cases where the intensity of the pain is more pronounced (p=0.0405, r=-0.421). In addition, analyzing the data by gender, it was observed that in the case of males, stiffness is more related to age (p=0.0079, r=0.7993), compared to women (p=0.0203, r=0.6223). In the case of women, the progression of the disease tends to increase more intensively total WOMAC score’s values (p=0.00031, r=0.8342), compared with men (p=0.0289, r=7013). Regarding interleukins and BMI, significant correlations were observed only in the case of men. Conclusions: A significant correlation between age and adiponectin, and adiponectin and IL-6, suggests that advanced age may contribute to adiponectin reduction. Comparing men with women, it was observed that men's age is more related to rigidity, and IL-6 and IL-10 are directly correlated to BMI and women seem to be more sensitive to pain and stiffness.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
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