Version 1
: Received: 29 February 2024 / Approved: 29 February 2024 / Online: 29 February 2024 (14:09:08 CET)
How to cite:
Wu, S.; Chen, Y.; Cheng, M.; Hsu, Y.; Hsieh, Y.; Yu, C. Si-Wu-Tang Promotes Cell Proliferation and Osteogenic Gene Expression during Osteoblastogenesis Yet Dampens the Formation of Osteoclast. Preprints2024, 2024021753. https://doi.org/10.20944/preprints202402.1753.v1
Wu, S.; Chen, Y.; Cheng, M.; Hsu, Y.; Hsieh, Y.; Yu, C. Si-Wu-Tang Promotes Cell Proliferation and Osteogenic Gene Expression during Osteoblastogenesis Yet Dampens the Formation of Osteoclast. Preprints 2024, 2024021753. https://doi.org/10.20944/preprints202402.1753.v1
Wu, S.; Chen, Y.; Cheng, M.; Hsu, Y.; Hsieh, Y.; Yu, C. Si-Wu-Tang Promotes Cell Proliferation and Osteogenic Gene Expression during Osteoblastogenesis Yet Dampens the Formation of Osteoclast. Preprints2024, 2024021753. https://doi.org/10.20944/preprints202402.1753.v1
APA Style
Wu, S., Chen, Y., Cheng, M., Hsu, Y., Hsieh, Y., & Yu, C. (2024). Si-Wu-Tang Promotes Cell Proliferation and Osteogenic Gene Expression during Osteoblastogenesis Yet Dampens the Formation of Osteoclast. Preprints. https://doi.org/10.20944/preprints202402.1753.v1
Chicago/Turabian Style
Wu, S., Ying-Chou Hsieh and Ching‑Hsiao Yu. 2024 "Si-Wu-Tang Promotes Cell Proliferation and Osteogenic Gene Expression during Osteoblastogenesis Yet Dampens the Formation of Osteoclast" Preprints. https://doi.org/10.20944/preprints202402.1753.v1
Abstract
Our results demonstrated that SWT stimulates osteoblastogenesis and increase the cell number of osteoblasts, suggesting positive regulatory effects on osteoblast differentiation. However, the effect of SWT on bone formation need further examination, since the expression of alp gene is downregulated. On the other hand, SWT appears to negatively regulate osteoclast differentiation and bone resorption, as number of osteoclasts and the expression of critical bone resorptive genes are all downregulated. Collectively, SWT might change the equilibrium of bone remodeling and increase the bone mass. Our data provided supportive evidences that this medicine formulation can be applied to treat osteoporosis or bone destructive diseases.
Keywords
Si-Wu-Tang; bone formation; bone resorption; osteoblastogenesis; osteoclastogenesis
Subject
Medicine and Pharmacology, Complementary and Alternative Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
