Version 1
: Received: 29 February 2024 / Approved: 29 February 2024 / Online: 29 February 2024 (10:11:48 CET)
How to cite:
Wasker, S. V. Z.; Beretov, J.; Millar, N.; Lam, P.; Murrell, G. A. C. Dendritic Cells, Th17 Cells & Tendinopathy. Preprints2024, 2024021711. https://doi.org/10.20944/preprints202402.1711.v1
Wasker, S. V. Z.; Beretov, J.; Millar, N.; Lam, P.; Murrell, G. A. C. Dendritic Cells, Th17 Cells & Tendinopathy. Preprints 2024, 2024021711. https://doi.org/10.20944/preprints202402.1711.v1
Wasker, S. V. Z.; Beretov, J.; Millar, N.; Lam, P.; Murrell, G. A. C. Dendritic Cells, Th17 Cells & Tendinopathy. Preprints2024, 2024021711. https://doi.org/10.20944/preprints202402.1711.v1
APA Style
Wasker, S. V. Z., Beretov, J., Millar, N., Lam, P., & Murrell, G. A. C. (2024). Dendritic Cells, Th17 Cells & Tendinopathy. Preprints. https://doi.org/10.20944/preprints202402.1711.v1
Chicago/Turabian Style
Wasker, S. V. Z., Patrick Lam and George A C Murrell. 2024 "Dendritic Cells, Th17 Cells & Tendinopathy" Preprints. https://doi.org/10.20944/preprints202402.1711.v1
Abstract
Background: Monocyte-derived dendritic cells (mo-DCs) play a vital role in the innate immune response by activating Th17 cells, which in turn release the pro-inflammatory cytokine IL-17. We hypothesised that following repetitive mechanical strain, tenocytes activate monocyte-derived dendritic cells, which in turn, drive the pathogenesis of tendinopathy. Aim: The aim of the study was to determine if monocyte-derived dendritic cells are upregulated in a human tendinopathy model. Method: Torn supraspinatus tendon and matched intact subscapularis tendon samples were collected from 7 patients undergoing arthroscopic shoulder surgery. Healthy control samples of subscapularis tendon were collected from 5 patients undergoing arthroscopic stabilization surgery. Tendon biopsy samples were evaluated immunohistochemically by quantifying the presence of monocyte-derived dendritic cells (CD11C and CD206). Results: Tendinopathic tendon samples exhibited significantly greater (2-3-fold) monocyte-derived dendritic cell expression when compared with healthy control tissue (P < .05). Conclusion: This study provides evidence for a monocyte-derived dendritic cell upregulation in early-stage human tendinopathy.
Medicine and Pharmacology, Orthopedics and Sports Medicine
Copyright:
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