Version 1
: Received: 21 February 2024 / Approved: 22 February 2024 / Online: 22 February 2024 (12:20:32 CET)
How to cite:
Mezgebo, D.T.; Tesfay, Y.R.; Pattnaik, G. Enhancing Cancer Therapy through Polymeric Nano-particles: Targeted Drug Delivery Strategies. Preprints2024, 2024021300. https://doi.org/10.20944/preprints202402.1300.v1
Mezgebo, D.T.; Tesfay, Y.R.; Pattnaik, G. Enhancing Cancer Therapy through Polymeric Nano-particles: Targeted Drug Delivery Strategies. Preprints 2024, 2024021300. https://doi.org/10.20944/preprints202402.1300.v1
Mezgebo, D.T.; Tesfay, Y.R.; Pattnaik, G. Enhancing Cancer Therapy through Polymeric Nano-particles: Targeted Drug Delivery Strategies. Preprints2024, 2024021300. https://doi.org/10.20944/preprints202402.1300.v1
APA Style
Mezgebo, D.T., Tesfay, Y.R., & Pattnaik, G. (2024). Enhancing Cancer Therapy through Polymeric Nano-particles: Targeted Drug Delivery Strategies. Preprints. https://doi.org/10.20944/preprints202402.1300.v1
Chicago/Turabian Style
Mezgebo, D.T., Yohannes Reda Tesfay and Guruduta Pattnaik. 2024 "Enhancing Cancer Therapy through Polymeric Nano-particles: Targeted Drug Delivery Strategies" Preprints. https://doi.org/10.20944/preprints202402.1300.v1
Abstract
Cancer, characterized by abnormal cell proliferation driven by genetic mutations, remains a significant health challenge. Tailoring effective therapies depends on factors like tumor location, grade, and stage, alongside patient condition. Leveraging Nano-carrier encapsulated drugs offers a promising avenue, as they accumulate preferentially at tumor sites, enhancing therapeutic efficacy while mitigating side effects. Polymeric Nano-carriers, with their customizable properties, further optimize drug delivery efficiency and specificity. Incorporating active targeting ligands such as antibodies, carbohydrates, peptides, folates, and aptamers-onto polymeric nanoparticle surfaces through techniques like functionalization, adsorption, and conjugation plays a pivotal role in directing therapeutic agents to tumor cells. Consequently, polymeric nanoparticles emerge as the carrier of choice for delivering drugs to various tumor types, including breast, colon, lung, prostate, liver, and spleen tumors.
Keywords
Polymeric Nanoparticle; Drug Delivery; Cancer; Ligands; Antibodies
Subject
Medicine and Pharmacology, Pharmacy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
