Version 1
: Received: 20 February 2024 / Approved: 20 February 2024 / Online: 20 February 2024 (13:32:33 CET)
How to cite:
Lin, H.; Gao, Z.; Asilebieke, A.; Guo, R.; Kan, Y.; Wang, Z.; Han, L.; Bo, W.; Han, L.; Qi, Y.; Xu, Y.; He, F.; Chu, J. A Review on the Promising Antibacterial Agents in Bone Cement-from Past to Current Insights. Preprints2024, 2024021148. https://doi.org/10.20944/preprints202402.1148.v1
Lin, H.; Gao, Z.; Asilebieke, A.; Guo, R.; Kan, Y.; Wang, Z.; Han, L.; Bo, W.; Han, L.; Qi, Y.; Xu, Y.; He, F.; Chu, J. A Review on the Promising Antibacterial Agents in Bone Cement-from Past to Current Insights. Preprints 2024, 2024021148. https://doi.org/10.20944/preprints202402.1148.v1
Lin, H.; Gao, Z.; Asilebieke, A.; Guo, R.; Kan, Y.; Wang, Z.; Han, L.; Bo, W.; Han, L.; Qi, Y.; Xu, Y.; He, F.; Chu, J. A Review on the Promising Antibacterial Agents in Bone Cement-from Past to Current Insights. Preprints2024, 2024021148. https://doi.org/10.20944/preprints202402.1148.v1
APA Style
Lin, H., Gao, Z., Asilebieke, A., Guo, R., Kan, Y., Wang, Z., Han, L., Bo, W., Han, L., Qi, Y., Xu, Y., He, F., & Chu, J. (2024). A Review on the Promising Antibacterial Agents in Bone Cement-from Past to Current Insights. Preprints. https://doi.org/10.20944/preprints202402.1148.v1
Chicago/Turabian Style
Lin, H., Fang He and Jian-jun Chu. 2024 "A Review on the Promising Antibacterial Agents in Bone Cement-from Past to Current Insights" Preprints. https://doi.org/10.20944/preprints202402.1148.v1
Abstract
Antibacterial bone cements (ABCs), such as antibiotic-loaded bone cements (ALBCs), have been widely utilized in clinical treatments. Currently, bone cements loaded with vancomycin, gentamicin, tobramycin, or clindamycin are approved by the US Food and Drug Administration. However, traditional ALBCs exhibit drawbacks like burst release and bacterial resistance. Therefore, there is a demand for the development of antibacterial bone cements containing novel agents. In this review, we summarize the latest advancements in ABCs. More importantly, we provide an overview and outlook on novel antibacterial agent-loaded bone cements, including metallic antibacterial agents, pH-switchable antibacterial agents, cationic polymers, N-halamines, non-leaching acrylic monomers, antimicrobial peptides, etc. Offering novel perspectives for designing ABCs and treating bone infections.
Keywords
bone cement; antibiotic; antibacterial agent; antimicrobial peptide; N-halamine; antimicrobial enzyme
Subject
Medicine and Pharmacology, Orthopedics and Sports Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
