Version 1
: Received: 13 February 2024 / Approved: 13 February 2024 / Online: 14 February 2024 (10:05:38 CET)
How to cite:
Nyolimati, C.A.; Mayito, J.; Obuya, E.; Atim, S.A.; Isingoma, E.; Kibombo, D.; Byonanebye, D.M.; Walwema, R.; Musoke, D.; Orach, C.G.; Kakooza, F. Prevalence and Factors Associated with Multidrug Resistant E. coli Carriage on Chicken Farms in West Nile Region in Uganda: A Cross-Sectional Survey. Preprints2024, 2024020789. https://doi.org/10.20944/preprints202402.0789.v1
Nyolimati, C.A.; Mayito, J.; Obuya, E.; Atim, S.A.; Isingoma, E.; Kibombo, D.; Byonanebye, D.M.; Walwema, R.; Musoke, D.; Orach, C.G.; Kakooza, F. Prevalence and Factors Associated with Multidrug Resistant E. coli Carriage on Chicken Farms in West Nile Region in Uganda: A Cross-Sectional Survey. Preprints 2024, 2024020789. https://doi.org/10.20944/preprints202402.0789.v1
Nyolimati, C.A.; Mayito, J.; Obuya, E.; Atim, S.A.; Isingoma, E.; Kibombo, D.; Byonanebye, D.M.; Walwema, R.; Musoke, D.; Orach, C.G.; Kakooza, F. Prevalence and Factors Associated with Multidrug Resistant E. coli Carriage on Chicken Farms in West Nile Region in Uganda: A Cross-Sectional Survey. Preprints2024, 2024020789. https://doi.org/10.20944/preprints202402.0789.v1
APA Style
Nyolimati, C.A., Mayito, J., Obuya, E., Atim, S.A., Isingoma, E., Kibombo, D., Byonanebye, D.M., Walwema, R., Musoke, D., Orach, C.G., & Kakooza, F. (2024). Prevalence and Factors Associated with Multidrug Resistant E. coli Carriage on Chicken Farms in West Nile Region in Uganda: A Cross-Sectional Survey. Preprints. https://doi.org/10.20944/preprints202402.0789.v1
Chicago/Turabian Style
Nyolimati, C.A., Christopher Garimoi Orach and Francis Kakooza. 2024 "Prevalence and Factors Associated with Multidrug Resistant E. coli Carriage on Chicken Farms in West Nile Region in Uganda: A Cross-Sectional Survey" Preprints. https://doi.org/10.20944/preprints202402.0789.v1
Abstract
Infections with multi-drug-resistant (MDR) pathogens in food-animals threaten public health and food security. However, the epidemiology and factors associated with MDR Escherichia coli on Ugandan farms are not well known. This study investigated the prevalence, resistance patterns and factors associated with MDR E. coli carriage on chicken farms. A total of 158 E. coli strains were isolated from 158 chicken farms. The disc diffusion method for susceptibility testing was performed. Clinical breakpoints were interpreted according to Clinical and Laboratory Standards Institute guidelines. MDR was defined as resistance to three or more classes of antimicrobials. MDR E. coli prevalence on chicken farms was 62.7% (95% CI: 55.0 – 70.3). High resistance was observed against ampicillin 79.8% (95% CI: 72.7–85.4), tetracycline 72.8% (95% CI: 65.2–79.2), cotrimoxazole 55.7% (95% CI: 47.8–63.3), and ciprofloxacin 38% (95% CI: 30.7–45.9). Farmers who were males (APR = 0.72, CI: 0.55, 0.93), and attained at least secondary education (APR=0.64, CI: 0.46, 0.88) and administration of recommended antibiotic doses (APR = 0.76, CI: 0.59–0.96) posed a lower risk of MDR E. coli carriage. Farms without footbaths posed a heighten risk (APR=1.48, CI: 1.16–1.88). MDR E. coli were highly prevalent on chicken farms. This study underscores the need for antimicrobial stewardship and improved infection prevention strategies on chicken farms.
Public Health and Healthcare, Public, Environmental and Occupational Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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