Version 1
: Received: 12 February 2024 / Approved: 13 February 2024 / Online: 13 February 2024 (12:34:06 CET)
How to cite:
Lloyd, S.; He, Y. Exploring Extracellular Matrix Crosslinking as a Therapeutic Approach to Fibrosis. Preprints2024, 2024020723. https://doi.org/10.20944/preprints202402.0723.v1
Lloyd, S.; He, Y. Exploring Extracellular Matrix Crosslinking as a Therapeutic Approach to Fibrosis. Preprints 2024, 2024020723. https://doi.org/10.20944/preprints202402.0723.v1
Lloyd, S.; He, Y. Exploring Extracellular Matrix Crosslinking as a Therapeutic Approach to Fibrosis. Preprints2024, 2024020723. https://doi.org/10.20944/preprints202402.0723.v1
APA Style
Lloyd, S., & He, Y. (2024). Exploring Extracellular Matrix Crosslinking as a Therapeutic Approach to Fibrosis. Preprints. https://doi.org/10.20944/preprints202402.0723.v1
Chicago/Turabian Style
Lloyd, S. and Yupeng He. 2024 "Exploring Extracellular Matrix Crosslinking as a Therapeutic Approach to Fibrosis" Preprints. https://doi.org/10.20944/preprints202402.0723.v1
Abstract
The extracellular matrix (ECM) provides structural support for tissues and regulatory signals for resident cells. ECM requires a careful balance between protein accumulation and degradation for homeostasis. Disruption of this balance can lead to pathological processes such as fibrosis in organs across the body. Post-translational crosslinking modifications to ECM proteins such as collagens alter ECM structure and function. Dysregulation of crosslinking enzymes as well as changes in crosslinking composition are prevalent in fibrosis. Because of the crucial roles that ECM crosslinking pathways play in disease, the enzymes that govern crosslinking events are being explored as therapeutic targets for fibrosis. Here we review in-depth the molecular mechanisms underlying ECM crosslinking, how ECM crosslinking contributes to fibrosis, and therapeutic strategies being explored to target ECM crosslinking in fibrosis to restore normal tissue structure and function.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
